Mrv0541 10211309572D 41 44 0 0 0 0 999 V2000 3.2734 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2734 -1.9484 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9426 -2.3667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6537 -1.9484 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6537 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9426 -0.7353 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9426 0.1013 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2734 0.5196 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5204 0.1013 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5204 -0.7353 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.2734 1.3561 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6537 0.5196 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.8094 0.5196 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9426 -3.2451 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4067 -2.4085 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4067 -0.7353 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1178 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1178 -1.9484 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8707 -2.3667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5818 -1.9484 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5818 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8707 -0.7353 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8707 0.1013 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 8.2929 -2.3667 0.0000 I 0 0 0 0 0 0 0 0 0 0 0 0 2.5204 -2.3667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8094 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0983 -0.7353 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3872 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3872 -1.9902 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0983 -2.3667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8094 -1.9484 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.3658 -0.7353 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -1.0769 -1.1536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7880 -0.7353 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0769 -1.9484 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 2.0672 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8551 2.0672 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8898 -1.4882 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 10.6143 -1.9065 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1654 -1.9065 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8898 -0.6517 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 1 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 8 9 1 0 0 0 0 9 10 1 0 0 0 0 1 10 1 0 0 0 0 8 11 1 0 0 0 0 7 12 2 0 0 0 0 9 13 2 0 0 0 0 3 14 2 0 0 0 0 4 15 1 0 0 0 0 5 16 1 0 0 0 0 16 17 1 0 0 0 0 17 18 2 0 0 0 0 18 19 1 0 0 0 0 19 20 2 0 0 0 0 20 21 1 0 0 0 0 21 22 2 0 0 0 0 17 22 1 0 0 0 0 22 23 1 0 0 0 0 20 24 1 0 0 0 0 2 25 1 0 0 0 0 10 26 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 28 29 2 0 0 0 0 29 30 1 0 0 0 0 30 31 2 0 0 0 0 26 31 1 0 0 0 0 28 32 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 35 2 0 0 0 0 36 37 1 0 0 0 0 37 11 1 0 0 0 0 11 36 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 38 41 2 0 0 0 0 M END > CHEBI:75991 > trametinib dimethyl sulfoxide > An addition compound obtained by combining equimolar amounts of trametinib and dimethyl sulfoxide. Used for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. > 3 > Trametinib DMSO; JTP 74057; GSK1120212B; GSK1120212 > N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1) > Mekinist > C28H29FIN5O5S; C26H23FIN5O4.C2H6OS > 693.52800 > 693.09181 > 0 > CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O > InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3 > OQUFJVRYDFIQBW-UHFFFAOYSA-N > 1187431-43-1 > 12497280 > 1187431-43-1 > DB08911 > D10176 > Trametinib > 21245089; 22169769; 22389471; 22507781; 23248257; 23432625; 23848983; 24025354; 24030134 $$$$