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M  END
> <ID>
CHEBI:149432

> <NAME>
6-de(cyclopropylamino)-6-(3-isopropoxyazetidin-1-yl)abacavir

> <DEFINITION>
A 2,6-diaminopurine that is an analogue of abacavir in which the cyclopropylamino group at position 6 of the purine moiety is replaced by a 3-isopropoxyazetidin-1-yl group. One of a series of synthesised abacavir analogues with antiviral activity found to stimulate IFN-γ secretion in abacavir-responsive clones.

> <STAR>
3

> <SYNONYM>
(1S,4R)-4-[2-amino-6-[3-(1-methylethoxy)-1-azetidinyl]-9H-purin-9-yl]-2-cyclopentene-1-methanol

> <IUPAC_NAME>
[(1S,4R)-4-(2-amino-6-{3-[(propan-2-yl)oxy]azetidin-1-yl}-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol

> <FORMULA>
C17H24N6O2

> <MASS>
344.419

> <MONOISOTOPIC_MASS>
344.19607

> <CHARGE>
0

> <SMILES>
[C@H]1(C=C[C@@H](C1)N2C=3C(N=C2)=C(N=C(N3)N)N4CC(C4)OC(C)C)CO

> <INCHI>
InChI=1S/C17H24N6O2/c1-10(2)25-13-6-22(7-13)15-14-16(21-17(18)20-15)23(9-19-14)12-4-3-11(5-12)8-24/h3-4,9-13,24H,5-8H2,1-2H3,(H2,18,20,21)/t11-,12+/m1/s1

> <INCHIKEY>
MALXRGLKOHFCJX-NEPJUHHUSA-N

> <PUBMED_CITATION>
31549414

$$$$