Marvin 03021215152D 37 39 0 0 0 0 999 V2000 6.5301 -4.7599 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.3928 -6.4099 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3928 -3.9349 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2454 -7.2349 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.8241 -9.7099 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5301 -6.4099 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.9612 -6.0024 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.1082 -6.4099 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.6772 -5.1774 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6772 -6.0024 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3928 -4.7599 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2458 -5.1774 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9615 -4.7599 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2458 -6.0024 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9615 -6.4099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1084 -7.6524 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3928 -7.2349 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1084 -5.1774 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5298 -7.6524 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8241 -8.8849 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1084 -8.4773 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8241 -7.2349 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5298 -8.4773 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8241 -4.7599 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5298 -5.1774 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2454 -4.7599 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5298 -6.0024 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9612 -5.1774 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2454 -6.4099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6768 -6.4099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3925 -6.0024 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9612 -7.6524 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1084 -10.1274 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8232 -5.9913 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 16.5432 -6.4013 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2375 -5.2738 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 15.4089 -5.2738 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 12 1 0 0 0 0 2 10 1 0 0 0 0 2 17 1 0 0 0 0 3 11 2 0 0 0 0 4 19 1 0 0 0 0 4 32 1 0 0 0 0 5 20 1 0 0 0 0 5 33 1 0 0 0 0 6 14 1 0 0 0 0 7 28 1 0 0 0 0 7 29 1 0 0 0 0 7 30 1 0 0 0 0 8 31 1 0 0 0 0 9 10 1 0 0 0 0 9 11 1 0 0 0 0 9 13 2 0 0 0 0 10 15 2 0 0 0 0 11 18 1 0 0 0 0 12 13 1 0 0 0 0 12 14 2 0 0 0 0 14 15 1 0 0 0 0 16 17 1 0 0 0 0 16 21 2 0 0 0 0 16 22 1 0 0 0 0 18 24 1 0 0 0 0 19 22 2 0 0 0 0 19 23 1 0 0 0 0 20 21 1 0 0 0 0 20 23 2 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 26 28 1 0 0 0 0 27 29 1 0 0 0 0 30 31 1 0 0 0 0 8 34 1 0 0 0 0 34 35 1 0 0 0 0 36 34 2 0 0 0 0 37 34 2 0 0 0 0 M END > CHEBI:64083 > RS 39604 > An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies. > 3 > RS67506; RS-67506 > C26H36ClN3O6S > 554.09900 > 553.20133 > 0 > COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 > InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3 > BKVIWGRFRKLFIO-UHFFFAOYSA-N > 8524141 > LSM-2461 > 11739263; 12095647; 15272208; 21689105; 7582507; 8903510; 9243330; 9689461 $$$$