Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens. Estrone can be converted into estradiol, and serves mainly as a precursor or metabolic intermediate of estradiol. It is both a precursor and metabolite of estradiol.
In addition to its role as a natural hormone, estrone has been used as a medication, for instance in menopausal hormone therapy; for information on estrone as a medication, see the estrone (medication) article. |
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InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 |
DNXHEGUUPJUMQT-CBZIJGRNSA-N |
[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21 |
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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estrogen
A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
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bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
3-hydroxyestra-1,3,5(10)-trien-17-one
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3-Hydroxy-1,3,5(10)-estratrien-17-one
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KEGG COMPOUND
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Estrone
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KEGG COMPOUND
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estrone
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UniProt
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follicular hormone
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NIST Chemistry WebBook
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folliculin
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NIST Chemistry WebBook
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oestrone
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NIST Chemistry WebBook
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3188
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DrugCentral
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C00003663
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KNApSAcK
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C00468
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KEGG COMPOUND
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D00067
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KEGG DRUG
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DB00655
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DrugBank
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Estrone
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Wikipedia
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FR1305992
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Patent
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HMDB0000145
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HMDB
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J3Z
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PDBeChem
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LMST02010004
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LIPID MAPS
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LSM-3837
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LINCS
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US1967350
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Patent
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US1967351
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Patent
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View more database links |
1915077
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Reaxys Registry Number
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Reaxys
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53-16-7
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CAS Registry Number
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KEGG COMPOUND
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53-16-7
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CAS Registry Number
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ChemIDplus
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53-16-7
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CAS Registry Number
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NIST Chemistry WebBook
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542591
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Gmelin Registry Number
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Gmelin
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