CHEBI:65138 - E-3810

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ChEBI Name E-3810
ChEBI ID CHEBI:65138
Definition A hydrochloride salt obtained by reaction of 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methyl-1-naphthamide with one equivalent of hydrochloric acid. E-3810 is a dual VEGFR and FGFR inhibitor
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
Supplier Information No supplier information found for this compound.
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Formula C26H26ClN3O4
Net Charge 0
Average Mass 479.95500
Monoisotopic Mass 479.16118
InChI InChI=1S/C26H25N3O4.ClH/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26;/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30);1H
InChIKey QHPVWTJTATVJBR-UHFFFAOYSA-N
SMILES Cl.CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12
Roles Classification
Biological Role(s): fibroblast growth factor receptor antagonist
An antagonist at the fibroblast growth factor receptor.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing E-3810 (CHEBI:65138) has part E-3810(1+) (CHEBI:65208)
E-3810 (CHEBI:65138) has role antineoplastic agent (CHEBI:35610)
E-3810 (CHEBI:65138) has role fibroblast growth factor receptor antagonist (CHEBI:63457)
E-3810 (CHEBI:65138) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
E-3810 (CHEBI:65138) is a hydrochloride (CHEBI:36807)
IUPAC Names
1-{[(6-methoxy-4-{[5-(methylcarbamoyl)-2-naphthyl]oxy}quinolin-7-yl)oxy]methyl}cyclopropanaminium chloride
6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methyl-1-naphthamide hydrochloride
Registry Number Type Source
22181391 Reaxys Registry Number Reaxys
Citation
Bello E, Colella G, Scarlato V, Oliva P, Berndt A, Valbusa G, Serra SC, D'Incalci M, Cavalletti E, Giavazzi R, Damia G, Camboni G (2011)
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models.
Cancer research 71, 1396-1405 [PubMed:21212416]
[show Abstract]
Last Modified
11 July 2012