norathyriol (CHEBI:7622)

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ChEBI Name	norathyriol

ChEBI ID	CHEBI:7622

Definition	A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:66635

Supplier Information	ChemicalBook:CB21387988, ZINC000006090922

Download	Molfile XML SDF

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Formula

C13H8O6

Net Charge

Average Mass

260.19900

Monoisotopic Mass

260.03209

InChI

InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H

InChIKey

ZHTQCPCDXKMMLU-UHFFFAOYSA-N

SMILES

Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O

Metabolite of Species	Details
Chlorophora tinctoria (IPNI:1131012-2)	See: DOI
Morus tinctoria (IPNI:164496-2)	See: DOI
Athyrium mesosorum (IPNI:17055670-1)	See: PubMed
Canscora decussata (IPNI:366549-1)	See: DOI
Garcinia echinocarpa (IPNI:427934-1)	See: DOI
Garcinia pedunculata (IPNI:428166-1)	See: DOI
Garcinia terpnophylla (IPNI:428266-1)	See: DOI
Cratoxylum pruniflorum (IPNI:433071-1)	See: PHARMAZIE,1988,43,879
Hypericum aucheri (IPNI:433222-1)	See: KHIMIYA PRIRODNYKH SOEDINENII,1980,2,256
Garcinia multiflora (NCBI:txid1009474)	See: DOI
Hypericum androsaemum (NCBI:txid140968)	See: DOI
Symphonia globulifera (NCBI:txid156483)	See: DOI
Anaxagorea luzonensis (NCBI:txid235716)	See: NATURAL MEDICINES,2001,55,316
Hypericum japonicum (NCBI:txid282542)	See: NAT PROD RES DEV,2004,16,511
Hypericum sampsonii (NCBI:txid282553)	See: PubMed
Maclura pomifera (NCBI:txid3496)	See: DOI
Allanblackia floribunda (NCBI:txid469914)	See: DOI
Ochrocarpos (NCBI:txid469946)	See: DOI
Pentaphalangium (NCBI:txid58227)	See: DOI
Garcinia mangostana (NCBI:txid58228)	See: DOI
Tripterospermum lanceolatum (NCBI:txid933376)	See: PubMed
Gymnocarpium robertianum (NCBI:txid983334)	See: YAKUGAKU ZASSHI,1986,106,378
Iris nigricans (NCBI:txid995810)	See: DOI
Mammea africana (NCBI:txid999584)	See: DOI

Roles Classification
Biological Role(s):	EC 2.7.11.13 (protein kinase C) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13). plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	norathyriol (CHEBI:7622) has role antineoplastic agent (CHEBI:35610) norathyriol (CHEBI:7622) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700) norathyriol (CHEBI:7622) has role plant metabolite (CHEBI:76924) norathyriol (CHEBI:7622) is a polyphenol (CHEBI:26195) norathyriol (CHEBI:7622) is a xanthones (CHEBI:51149)

Incoming	tripteroside (CHEBI:9746) has functional parent norathyriol (CHEBI:7622)

IUPAC Name

1,3,6,7-tetrahydroxy-9H-xanthen-9-one

Last Modified

03 October 2014

General Comments
2012-07-27	YAKUGAKU ZASSHI,1986,106,378
2012-07-27	NAT PROD RES DEV,2004,16,511
2012-07-27	KHIMIYA PRIRODNYKH SOEDINENII,1980,2,256
2012-07-27	PHARMAZIE,1988,43,879
2012-07-27	NATURAL MEDICINES,2001,55,316