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> Main
CHEBI:65209 - E-3810 free base
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ChEBI Ontology
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ChEBI Name
E-3810 free base
ChEBI ID
CHEBI:65209
Definition
A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine.
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
ChemicalBook:CB62624136
,
ZINC000077024213
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Formula
C26H25N3O4
Net Charge
0
Average Mass
443.49440
Monoisotopic Mass
443.18451
InChI
InChI=1S/C26H25N3O4/c1-
28-
25(30)
19-
5-
3-
4-
16-
12-
17(6-
7-
18(16)
19)
33-
22-
8-
11-
29-
21-
14-
24(23(31-
2)
13-
20(21)
22)
32-
15-
26(27)
9-
10-
26/h3-
8,11-
14H,9-
10,15,27H2,1-
2H3,(H,28,30)
InChIKey
CUDVHEFYRIWYQD-UHFFFAOYSA-N
SMILES
CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12
Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
fibroblast growth factor receptor antagonist
An antagonist at the fibroblast growth factor receptor.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
E-3810 free base (
CHEBI:65209
)
has role
antineoplastic agent (
CHEBI:35610
)
E-3810 free base (
CHEBI:65209
)
has role
fibroblast growth factor receptor antagonist (
CHEBI:63457
)
E-3810 free base (
CHEBI:65209
)
has role
vascular endothelial growth factor receptor antagonist (
CHEBI:65207
)
E-3810 free base (
CHEBI:65209
)
is a
aromatic ether (
CHEBI:35618
)
E-3810 free base (
CHEBI:65209
)
is a
cyclopropanes (
CHEBI:51454
)
E-3810 free base (
CHEBI:65209
)
is a
naphthalenecarboxamide (
CHEBI:48739
)
E-3810 free base (
CHEBI:65209
)
is a
primary amino compound (
CHEBI:50994
)
E-3810 free base (
CHEBI:65209
)
is a
quinolines (
CHEBI:26513
)
E-3810 free base (
CHEBI:65209
)
is conjugate base of
E-3810(1+) (
CHEBI:65208
)
Incoming
E-3810(1+) (
CHEBI:65208
)
is conjugate acid of
E-3810 free base (
CHEBI:65209
)
IUPAC Name
6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-
N
-methyl-1-naphthamide
Synonym
Source
E-3810 amine
ChEBI
Registry Number
Type
Source
18478470
Reaxys Registry Number
Reaxys
Last Modified
06 March 2014