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metronidazole |
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CHEBI:6909 |
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A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
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![](images/goldenstar.gif) ![](images/goldenstar.gif)
This entity has been manually annotated by the ChEBI Team.
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Anonymous
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CHEBI:39845, CHEBI:63636
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ChemicalBook:CB2724915, eMolecules:509860, ZINC000000097471 |
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SDF
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more structures >>
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Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. Discovered in 1965, aspartame was approved by the US Food and Drug Administration (FDA) in 1974 and re-approved in 1981 after its initial approval was briefly revoked.
Aspartame is one of the most studied food additives in the human food supply. Reviews by over 100 governmental regulatory bodies found the ingredient safe for consumption at the normal acceptable daily intake limit. |
Read full article at Wikipedia
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InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3 |
VAOCPAMSLUNLGC-UHFFFAOYSA-N |
Cc1ncc(n1CCO)[N+]([O-])=O |
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environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
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antitrichomonal drug
A drug used to treat trichomonas infections.
antibacterial drug
A drug used to treat or prevent bacterial infections.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
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antitrichomonal drug
A drug used to treat trichomonas infections.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antibacterial drug
A drug used to treat or prevent bacterial infections.
antiparasitic agent
A substance used to treat or prevent parasitic infections.
radiosensitizing agent
A drug that makes increases the sensitivity of tumour cells to radiation therapy.
antiamoebic agent
An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae.
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View more via ChEBI Ontology
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
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metronidazol
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WHO MedNet
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metronidazole
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KEGG DRUG
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métronidazole
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WHO MedNet
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metronidazolum
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WHO MedNet
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1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
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ChemIDplus
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1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
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ChemIDplus
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1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
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NIST Chemistry WebBook
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1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
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ChemIDplus
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1-(β-oxyethyl)-2-methyl-5-nitroimidazole
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ChemIDplus
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2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
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ChemIDplus
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2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
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2-methyl-5-nitroimidazole-1-ethanol
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ChemIDplus
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443-48-1
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CAS Registry Number
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NIST Chemistry WebBook
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443-48-1
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CAS Registry Number
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ChemIDplus
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611683
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11906111
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