Ergocalciferol, also known as vitamin D2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement to prevent and treat vitamin D deficiency due to poor absorption by the intestines or liver disease. It may also be used for low blood calcium due to hypoparathyroidism. It is taken by mouth or via injection into a muscle.
Excessive doses can result in vitamin D toxicity causing increased urine production, high blood pressure, kidney stones, kidney failure, muscle weakness, and constipation. If high doses are taken for a long period of time, tissue calcification may occur. Normal doses are safe in pregnancy. It works by increasing the amount of calcium absorbed by the intestines and reabsorbed by the kidneys. Food in which it is found include some mushrooms.
Ergocalciferol was first described in 1936. Ergocalciferol is available as a generic medication and over the counter. In 2022, it was the 38th most commonly prescribed medication in the United States, with more than 15 million prescriptions. Certain foods such as breakfast cereal and margarine have ergocalciferol added to them in some countries. It is on the World Health Organization's List of Essential Medicines.
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InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 |
KZSNJWFQEVHDMF-BYPYZUCNSA-N |
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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Chlamydomonas reinhardtii
(NCBI:txid3055)
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See:
PubMed
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Saccharomyces cerevisiae
(NCBI:txid4932)
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Source: yeast.sf.net
See:
PubMed
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Escherichia coli
(NCBI:txid562)
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PubMed
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Homo sapiens
(NCBI:txid9606)
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DOI
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Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
micronutrient
Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
algal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
(via valine )
Daphnia magna metabolite
A Daphnia metabolite produced by the species Daphnia magna.
(via valine )
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nutraceutical
A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
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View more via ChEBI Ontology
(2S)-2-amino-3-methylbutanoic acid
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IUPAC
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(S)-valine
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ChemIDplus
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2-Amino-3-methylbutyric acid
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KEGG COMPOUND
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L-(+)-alpha-Aminoisovaleric acid
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HMDB
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L-alpha-Amino-beta-methylbutyric acid
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HMDB
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L-Valin
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ChEBI
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L-Valine
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KEGG COMPOUND
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V
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ChEBI
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Val
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ChEBI
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VALINE
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PDBeChem
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4128
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DrugCentral
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C00001398
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KNApSAcK
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C00183
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KEGG COMPOUND
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D00039
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KEGG DRUG
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DB00161
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DrugBank
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HMDB0000883
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HMDB
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L-valine
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Wikipedia
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VAL
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MetaCyc
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VAL
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PDBeChem
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View more database links |
1721136
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Reaxys Registry Number
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Reaxys
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2827
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Gmelin Registry Number
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Gmelin
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72-18-4
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CAS Registry Number
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KEGG COMPOUND
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72-18-4
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CAS Registry Number
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ChemIDplus
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72-18-4
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CAS Registry Number
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NIST Chemistry WebBook
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14608070
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PubMed citation
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Europe PMC
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17670823
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PubMed citation
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Europe PMC
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21706252
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PubMed citation
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Europe PMC
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22138982
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PubMed citation
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Europe PMC
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22287678
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PubMed citation
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Europe PMC
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22585822
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PubMed citation
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Europe PMC
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