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ChEBI
> Main
CHEBI:91107 - SB 415286
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ChEBI Name
SB 415286
ChEBI ID
CHEBI:91107
Definition
A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively.
Stars
This entity has been manually annotated by the ChEBI Team.
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Formula
C16H10ClN3O5
Net Charge
0
Average Mass
359.721
Monoisotopic Mass
359.03090
InChI
InChI=1S/C16H10ClN3O5/c17-
10-
7-
8(5-
6-
12(10)
21)
18-
14-
13(15(22)
19-
16(14)
23)
9-
3-
1-
2-
4-
11(9)
20(24)
25/h1-
7,21H,(H2,18,19,22,23)
InChIKey
PQCXVIPXISBFPN-UHFFFAOYSA-N
SMILES
N1C(C(=C(C1=O)NC2=CC=C(C(=C2)Cl)O)C3=CC=CC=C3[N+]([O-])=O)=O
Roles Classification
Chemical Role
(s):
antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
EC 2.7.11.26 (tau-protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of
tau
-protein kinase inhibitor (EC 2.7.11.26).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application
(s):
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
SB 415286 (
CHEBI:91107
)
has role
antioxidant (
CHEBI:22586
)
SB 415286 (
CHEBI:91107
)
has role
apoptosis inducer (
CHEBI:68495
)
SB 415286 (
CHEBI:91107
)
has role
EC 2.7.11.26 (
tau
-protein kinase) inhibitor (
CHEBI:91092
)
SB 415286 (
CHEBI:91107
)
has role
neuroprotective agent (
CHEBI:63726
)
SB 415286 (
CHEBI:91107
)
is a
C
-nitro compound (
CHEBI:35716
)
SB 415286 (
CHEBI:91107
)
is a
maleimides (
CHEBI:55417
)
SB 415286 (
CHEBI:91107
)
is a
monochlorobenzenes (
CHEBI:83403
)
SB 415286 (
CHEBI:91107
)
is a
phenols (
CHEBI:33853
)
SB 415286 (
CHEBI:91107
)
is a
secondary amino compound (
CHEBI:50995
)
SB 415286 (
CHEBI:91107
)
is a
substituted aniline (
CHEBI:48975
)
IUPAC Name
3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)-1
H
-pyrrole-2,5-dione
Synonyms
Sources
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
ChemIDplus
SB-415286
ChemIDplus
SB415286
ChEBI
Manual Xref
Database
LSM-3719
LINCS
View more database links
Registry Numbers
Types
Sources
264218-23-7
CAS Registry Number
ChemIDplus
8795652
Reaxys Registry Number
Reaxys
Citations
Types
Sources
11279265
PubMed citation
Europe PMC
11696357
PubMed citation
Europe PMC
12950267
PubMed citation
Europe PMC
12960765
PubMed citation
Europe PMC
14729058
PubMed citation
Europe PMC
15950778
PubMed citation
Europe PMC
18342477
PubMed citation
Europe PMC
18502415
PubMed citation
Europe PMC
18938143
PubMed citation
Europe PMC
22776263
PubMed citation
Europe PMC
23871716
PubMed citation
Europe PMC
24176578
PubMed citation
Europe PMC
24228880
PubMed citation
Europe PMC
Last Modified
23 January 2023