Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. Studies have shown that venlafaxine improves post-traumatic stress disorder (PTSD). It may also be used for chronic neuropathic pain. It is taken orally (swallowed by mouth). It is also available as the salt venlafaxine besylate (venlafaxine benzenesulfonate monohydrate) in an extended-release formulation (Venbysi XR).
Common side effects include loss of appetite, constipation, dry mouth, dizziness, sweating, insomnia, drowsiness and sexual problems. Severe side effects include an increased risk of suicide, mania, and serotonin syndrome. Antidepressant withdrawal syndrome may occur if stopped. There are concerns that use during the later part of pregnancy can harm the baby. How it works is not entirely clear, but it seems to be related to the potentiation of the activity of some neurotransmitters in the brain.
Venlafaxine was approved for medical use in the United States in 1993. It is available as a generic medication. In 2022, it was the 44th most commonly prescribed medication in the United States, with more than 13 million prescriptions.
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InChI=1S/C19H16/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,19H |
AAAQKTZKLRYKHR-UHFFFAOYSA-N |
c1ccc(cc1)C(c1ccccc1)c1ccccc1 |
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environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
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xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
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View more via ChEBI Ontology
1,1',1''-methanetriyltribenzene
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1,1',1''-methylidynetrisbenzene
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ChEBI
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1,1,1-triphenylmethane
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ChEBI
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Tritane
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ChemIDplus
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1909753
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Reaxys Registry Number
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Reaxys
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519-73-3
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CAS Registry Number
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ChemIDplus
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22573270
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PubMed citation
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Europe PMC
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23008002
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PubMed citation
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Europe PMC
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23053116
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PubMed citation
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Europe PMC
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23341885
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PubMed citation
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Europe PMC
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23865508
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PubMed citation
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Europe PMC
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24136473
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PubMed citation
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Europe PMC
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