CHEBI:133014 - pimavanserin tartrate

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name pimavanserin tartrate
ChEBI ID CHEBI:133014
Definition A tartrate salt that is the hemitartrate salt of pimavanserin. An atypical antipsychotic that is used for treatment of hallucinations and delusions associated with Parkinson's disease.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C54H74F2N6O10
Net Charge 0
Average Mass 1005.198
Monoisotopic Mass 1004.54345
InChI InChI=1S/2C25H34FN3O2.C4H6O6/c2*1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21;5-1(3(7)8)2(6)4(9)10/h2*4-11,19,23H,12-18H2,1-3H3,(H,27,30);1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
InChIKey RGSULKHNAKTFIZ-CEAXSRTFSA-N
SMILES C1=C(C=CC(=C1)CNC(N(C2CCN(CC2)C)CC3=CC=C(C=C3)F)=O)OCC(C)C.OC([C@@H]([C@H](C(O)=O)O)O)=O.C1=C(C=CC(=C1)CNC(N(C2CCN(CC2)C)CC3=CC=C(C=C3)F)=O)OCC(C)C
Roles Classification
Biological Role(s): serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
5-hydroxytryptamine 2A receptor inverse agonist
An inverse agonist that binds to the same receptor as a 5-hydroxytryptamine 2A receptor agonist, but which induces a pharmacological response opposite to that agonist.
Application(s): antipsychotic agent
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing pimavanserin tartrate (CHEBI:133014) has part pimavanserin(1+) (CHEBI:133020)
pimavanserin tartrate (CHEBI:133014) has role 5-hydroxytryptamine 2A receptor inverse agonist (CHEBI:133016)
pimavanserin tartrate (CHEBI:133014) has role antipsychotic agent (CHEBI:35476)
pimavanserin tartrate (CHEBI:133014) has role serotonergic antagonist (CHEBI:48279)
pimavanserin tartrate (CHEBI:133014) is a tartrate salt (CHEBI:50562)
IUPAC Names
bis(4-{[(4-fluorophenyl)methyl]({[4-(2-methylpropoxy)phenyl]methyl}carbamoyl)amino}-1-methylpiperidin-1-ium) (2R,3R)-2,3-dihydroxybutanedioate
bis{N-[(4-fluorophenyl)methyl]-N-(1-methylpiperidin-4-yl)-N'-{[4-(2-methylpropoxy)phenyl]methyl}urea} (2R,3R)-2,3-dihydroxybutanedioate
Synonyms Sources
ACP 103 ChemIDplus
ACP-103 ChemIDplus
Bis(1-(4-Fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate ChemIDplus
pimavanserin hemitartrate ChEBI
Brand Name Source
Nuplazid KEGG DRUG
Manual Xrefs Databases
D08969 KEGG DRUG
NZ541146 Patent
Pimavanserin Wikipedia
View more database links
Registry Numbers Types Sources
10410569 Reaxys Registry Number Reaxys
706782-28-7 CAS Registry Number ChemIDplus
706782-28-7 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
16220333 PubMed citation Europe PMC
16469866 PubMed citation Europe PMC
16869120 PubMed citation Europe PMC
17473118 PubMed citation Europe PMC
17495279 PubMed citation Europe PMC
17519387 PubMed citation Europe PMC
17708779 PubMed citation Europe PMC
18534670 PubMed citation Europe PMC
19040345 PubMed citation Europe PMC
19864614 PubMed citation Europe PMC
21256805 PubMed citation Europe PMC
26908168 PubMed citation Europe PMC
Last Modified
16 August 2016