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ChEBI
> Main
CHEBI:36332 - hispidin
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ChEBI Name
hispidin
ChEBI ID
CHEBI:36332
Definition
Fungal metabolite first found in basidiomycete
Inonotus hispidus
(formerly
Polyporus hispidus
).
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
No supplier information found for this compound.
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Wikipedia
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Aphidicolin is a tetracyclic
diterpene
antibiotic
isolated from the fungus
Cephalosporum aphidicola
with antiviral and antimitotic properties. Aphidicolin is a reversible
inhibitor
of
eukaryotic
nuclear
DNA
replication. It blocks the cell cycle at early
S phase
. It is a specific inhibitor of
DNA polymerase Alpha
and
Delta
in eukaryotic cells and in some viruses (
vaccinia
and
herpesviruses
) and an
apoptosis
inducer in
HeLa
cells. Natural aphidicolin is a secondary metabolite of the fungus
Nigrospora oryzae
.
Read full article at Wikipedia
Formula
C13H10O5
Net Charge
0
Average Mass
246.218
Monoisotopic Mass
246.05282
InChI
InChI=1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
InChIKey
SGJNQVTUYXCBKH-HNQUOIGGSA-N
SMILES
OC1=CC(=O)OC(\C=C\C2=CC=C(O)C(O)=C2)=C1
Metabolite of Species
Details
Phaeolus schweinitzii
(NCBI:txid40476)
See:
PubMed
Roles Classification
Chemical Role
(s):
antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role
(s):
fungal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
EC 2.7.11.13 (protein kinase C) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
hispidin (
CHEBI:36332
)
has role
antioxidant (
CHEBI:22586
)
hispidin (
CHEBI:36332
)
has role
EC 2.7.11.13 (protein kinase C) inhibitor (
CHEBI:37700
)
hispidin (
CHEBI:36332
)
has role
fungal metabolite (
CHEBI:76946
)
hispidin (
CHEBI:36332
)
is a
2-pyranones (
CHEBI:75885
)
hispidin (
CHEBI:36332
)
is a
catechols (
CHEBI:33566
)
hispidin (
CHEBI:36332
)
is conjugate acid of
hispidin(1−) (
CHEBI:190288
)
Incoming
hispidin(1−) (
CHEBI:190288
)
is conjugate base of
hispidin (
CHEBI:36332
)
IUPAC Name
6-[(
E
)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxy-2
H
-pyran-2-one
Synonyms
Sources
6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone
ChemIDplus
6-[(
E
)-2-(3,4-dihydroxyphenyl)vinyl]-4-hydroxy-2
H
-pyran-2-one
IUPAC
hispidin
ChemIDplus
Manual Xrefs
Databases
13975015
ChemSpider
C00043575
KNApSAcK
Hispidin
Wikipedia
HMDB0253181
HMDB
View more database links
Registry Numbers
Types
Sources
1288087
Beilstein Registry Number
Beilstein
555-55-5
CAS Registry Number
ChemIDplus
Citations
Types
Sources
29345559
PubMed citation
Europe PMC
32321407
PubMed citation
Europe PMC
34335912
PubMed citation
Europe PMC
35067200
PubMed citation
Europe PMC
565401
PubMed citation
Europe PMC
9088624
PubMed citation
Europe PMC
Last Modified
25 March 2022