Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae. |
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InChI=1S/C20H28O9/c1-2-3-4-5-6-7-8-9-13-12-28-20(16(13)23)10-14(17(24)25)19(29-20,18(26)27)11-15(21)22/h12,14H,2-11H2,1H3,(H,21,22)(H,24,25)(H,26,27) |
LQLCHKHILFZNKF-UHFFFAOYSA-N |
CCCCCCCCCC1=COC2(CC(C(O)=O)C(CC(O)=O)(O2)C(O)=O)C1=O |
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Talaromyces trachyspermus
(NCBI:txid28566)
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of strain
SANK 12191
See:
PubMed
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Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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fungal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
EC 3.2.1.166 (heparanase) inhibitor
An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of heparanase (EC 3.2.1.166).
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View more via ChEBI Ontology
2-(carboxymethyl)-8-nonyl-9-oxo-1,6-dioxaspiro[4.4]non-7-ene-2,3-dicarboxylic acid
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149718-37-6
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CAS Registry Number
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ChemIDplus
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7318108
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Reaxys Registry Number
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Reaxys
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12633090
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PubMed citation
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Europe PMC
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15917891
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PubMed citation
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Europe PMC
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17700851
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PubMed citation
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Europe PMC
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21879704
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PubMed citation
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Europe PMC
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7797435
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PubMed citation
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Europe PMC
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