| Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
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Read full article at Wikipedia
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InChI=1S/C12H9F3N2O2/c1- 7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7- |
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| C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
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EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor
An EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor that interferes with the action of dihydroorotate oxidase (fumarate), EC 1.3.98.1 (formerly EC 1.3.3.1).
tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
hepatotoxic agent
A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals.
drug metabolite
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non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
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View more via ChEBI Ontology
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(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
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teriflunomida
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WHO MedNet
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teriflunomide
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ChemIDplus
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tériflunomide
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WHO MedNet
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teriflunomidum
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WHO MedNet
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(Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide
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ChemIDplus
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A 77-1726
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ChemIDplus
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A 771726
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ChemIDplus
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HMR 1726
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ChemIDplus
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HMR1726
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ChemIDplus
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163451-81-8
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CAS Registry Number
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KEGG DRUG
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163451-81-8
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CAS Registry Number
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ChemIDplus
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6655982
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Reaxys Registry Number
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Reaxys
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