InChI=1S/C12H11N3O2/c1-17-10-6-9(8-14-16)15-12(7-10)11-4-2-3-5-13-11/h2-8,16H,1H3/b14-8+ |
JCTRJRHLGOKMCF-RIYZIHGNSA-N |
COc1cc(\C=N\O)nc(c1)-c1ccccn1 |
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Actinoalloteichus cyanogriseus
(NCBI:txid65497)
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Ethyl acetate extract of fermentation broth
of strain
WH1 2216-6
See:
PubMed
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bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
marine metabolite
Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
(E)-N-hydroxy-1-(4-methoxy-2,2ʼ-bipyridin-6-yl)methanimine
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(E)-4-methoxy-(2,2ʼ-bipyridine)-6-carbaldehyde oxime
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ChemIDplus
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(E)-4-methoxy-2,2ʼ-bipyridyl-6-aldoxime
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ChEBI
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cerulomycin
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ChemIDplus
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15421
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Reaxys Registry Number
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Reaxys
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21802-37-9
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CAS Registry Number
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ChemIDplus
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Fu P, Wang S, Hong K, Li X, Liu P, Wang Y, Zhu W (2011) Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. Journal of natural products 74, 1751-1756 [PubMed:21770434] [show Abstract] Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC₅₀ values of 0.26 to 15.7 μM. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 μM. |
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