CHEBI:91418 - foretinib

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ChEBI Name foretinib
ChEBI ID CHEBI:91418
Definition A quinoline substituted by 2-fluoro-4-[({1-[(4-fluorophenyl)carbamoyl]cyclopropyl}carbonyl)amino]phenoxy, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 4, 6 and 7, respectively. It is a multi-kinase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C34H34F2N4O6
Net Charge 0
Average Mass 632.665
Monoisotopic Mass 632.24464
InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
InChIKey CXQHYVUVSFXTMY-UHFFFAOYSA-N
SMILES COC1=CC2=C(OC3=C(F)C=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)C=CN=C2C=C1OCCCN1CCOCC1
Roles Classification
Biological Role(s): c-Met tyrosine kinase inhibitor
An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing foretinib (CHEBI:91418) has role antineoplastic agent (CHEBI:35610)
foretinib (CHEBI:91418) has role apoptosis inducer (CHEBI:68495)
foretinib (CHEBI:91418) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
foretinib (CHEBI:91418) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
foretinib (CHEBI:91418) is a aromatic ether (CHEBI:35618)
foretinib (CHEBI:91418) is a cyclopropanes (CHEBI:51454)
foretinib (CHEBI:91418) is a dicarboxylic acid diamide (CHEBI:35779)
foretinib (CHEBI:91418) is a monofluorobenzenes (CHEBI:83575)
foretinib (CHEBI:91418) is a morpholines (CHEBI:38785)
foretinib (CHEBI:91418) is a quinolines (CHEBI:26513)
IUPAC Name
N1-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
INNs Sources
foretinib WHO MedNet
forétinib WHO MedNet
foretinib WHO MedNet
foretinibum WHO MedNet
Synonyms Sources
1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide ChEBI
EXEL 2880 ChEBI
EXEL-2880 DrugBank
EXEL2880 ChEBI
GSK 1363089G ChEBI
GSK-089 DrugBank
GSK-1363089 DrugBank
GSK089 DrugBank
GSK1363089 DrugBank
N-[3-fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide ChEBI
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide ChEBI
XL 880 DrugBank
XL-880 DrugBank
XL880 DrugBank
Manual Xrefs Databases
88Z PDBeChem
D09618 KEGG DRUG
DB12307 DrugBank
Foretinib Wikipedia
HMDB0252437 HMDB
LSM-1158 LINCS
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Registry Number Type Source
849217-64-7 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
16 July 2024