CHEBI:173097 - liproxstatin-1

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ChEBI Name liproxstatin-1
ChEBI ID CHEBI:173097
Definition An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB0259026, eMolecules:35875953, eMolecules:12800964, ZINC000031155604
Download Molfile XML SDF
Formula C19H21ClN4
Net Charge 0
Average Mass 340.860
Monoisotopic Mass 340.14547
InChI InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChIKey YAFQFNOUYXZVPZ-UHFFFAOYSA-N
SMILES ClC1=CC(CNC2=NC3=CC=CC=C3NC22CCNCC2)=CC=C1
Roles Classification
Chemical Role(s): radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): ferroptosis inhibitor
Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Application(s): cardioprotective agent
Any protective agent that is able to prevent damage to the heart.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing liproxstatin-1 (CHEBI:173097) has role antioxidant (CHEBI:22586)
liproxstatin-1 (CHEBI:173097) has role cardioprotective agent (CHEBI:77307)
liproxstatin-1 (CHEBI:173097) has role ferroptosis inhibitor (CHEBI:173084)
liproxstatin-1 (CHEBI:173097) has role radical scavenger (CHEBI:48578)
liproxstatin-1 (CHEBI:173097) is a azaspiro compound (CHEBI:35624)
liproxstatin-1 (CHEBI:173097) is a monochlorobenzenes (CHEBI:83403)
liproxstatin-1 (CHEBI:173097) is a organic heterotricyclic compound (CHEBI:26979)
liproxstatin-1 (CHEBI:173097) is a secondary amino compound (CHEBI:50995)
IUPAC Name
N-(3-chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
Synonyms Sources
Lip-1 ChEBI
liproxstatin 1 ChEBI
liproxstatin1 ChEBI
N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine IUPAC
Manual Xref Database
20387119 ChemSpider
View more database links
Registry Number Type Source
950455-15-9 CAS Registry Number ChEBI
Citations Types Sources
28386601 PubMed citation Europe PMC
28489094 PubMed citation Europe PMC
28975372 PubMed citation Europe PMC
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33735625 PubMed citation Europe PMC
33827043 PubMed citation Europe PMC
33889074 PubMed citation Europe PMC
33974796 PubMed citation Europe PMC
Last Modified
27 May 2021