CHEBI:90990 - 12,20-DiHETE

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ChEBI Name 12,20-DiHETE
ChEBI ID CHEBI:90990
Definition A DiHETE that is 12-HETE carrying an additional hydroxy substituent at position 20.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ZINC000143093236
Download Molfile XML SDF
Formula C20H32O4
Net Charge 0
Average Mass 336.466
Monoisotopic Mass 336.23006
InChI InChI=1S/C20H32O4/c21-18-14-10-6-5-8-12-16-19(22)15-11-7-3-1-2-4-9-13-17-20(23)24/h2-4,7-8,11-12,15,19,21-22H,1,5-6,9-10,13-14,16-18H2,(H,23,24)/b4-2-,7-3-,12-8-,15-11+
InChIKey NUPDGIJXOAHJRW-LNESKJDXSA-N
SMILES C(=C\C(C/C=C\CCCCCO)O)/C=C\C/C=C\CCCC(=O)O
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): human xenobiotic metabolite
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 12,20-DiHETE (CHEBI:90990) has functional parent (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid (CHEBI:84447)
12,20-DiHETE (CHEBI:90990) has role human xenobiotic metabolite (CHEBI:76967)
12,20-DiHETE (CHEBI:90990) is a ω-hydroxy-long-chain fatty acid (CHEBI:140997)
12,20-DiHETE (CHEBI:90990) is a dihydroxyicosatetraenoic acid (CHEBI:72868)
12,20-DiHETE (CHEBI:90990) is conjugate acid of 12,20-DiHETE(1−) (CHEBI:90719)
Incoming 12,20-DiHETE(1−) (CHEBI:90719) is conjugate base of 12,20-DiHETE (CHEBI:90990)
IUPAC Name
(5Z,8Z,10E,14Z)-12,20-dihydroxyicosa-5,8,10,14-tetraenoic acid
Synonyms Sources
(5Z,8Z,10E,14Z)-12,20-dihydroxyicosatetraenoic acid ChEBI
12,20-dihydroxy-(5Z,8Z,10E,14Z)-icosatetraenoic acid ChEBI
Manual Xref Database
HMDB0060105 HMDB
View more database links
Registry Number Type Source
24406269 Reaxys Registry Number Reaxys
Citations
Kalsotra A, Turman CM, Kikuta Y, Strobel HW (2004)
Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.
Toxicology and applied pharmacology 199, 295-304 [PubMed:15364545]
[show Abstract]
Kikuta Y, Kusunose E, Sumimoto H, Mizukami Y, Takeshige K, Sakaki T, Yabusaki Y, Kusunose M (1998)
Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).
Archives of biochemistry and biophysics 355, 201-205 [PubMed:9675028]
[show Abstract]
Rosolowsky M, Falck JR, Campbell WB (1996)
Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites.
Biochimica et biophysica acta 1300, 143-150 [PubMed:8652640]
[show Abstract]
Hajjar DP, Pomerantz KB (1989)
Eicosanoids and their role in atherosclerosis.
Archives des maladies du coeur et des vaisseaux 82 Spec No 4, 21-26 [PubMed:2514663]
[show Abstract]
Last Modified
24 January 2023