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(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl group |
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CHEBI:85932 |
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(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl group |
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A fatty-acyl group derived from (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid. |
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This entity has been manually annotated by the ChEBI Team.
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Kristian Axelsen
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Molfile
XML
SDF
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more structures >>
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C(\C/C=C\C/C=C\C/C=C\CC)=C\C/C=C\C/C=C\CCC(=O)* |
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Outgoing
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(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl group
(CHEBI:85932)
is a
fatty-acyl group
(CHEBI:24027)
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl group
(CHEBI:85932)
is substituent group from
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid
(CHEBI:28125)
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(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl group
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ChEBI
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(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl group
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UniProt
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all-cis-docosa-4,7,10,13,16,19-hexaenoyl group
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ChEBI
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Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP (2007) Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. Phytochemistry 68, 785-796 (Source: SUBMITTER) [PubMed:17291553] [show Abstract] The marine microalga Pavlova salina produces lipids containing approximately 50% omega-3 long chain polyunsaturated fatty acids (LC-PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Three cDNA sequences, designated PsD4Des, PsD5Des, PsD8Des, were isolated from P. salina and shown to encode three front-end desaturases with Delta4, Delta5 and Delta8 specificity, respectively. Southern analysis indicated that the P. salina genome contained single copies of all three front-end fatty acid desaturase genes. When grown at three different temperatures, analysis of fatty acid profiles indicated P. salina desaturation conversions occurred with greater than 95% efficiency. Real-Time PCR revealed that expression of PsD8Des was higher than for the other two genes under normal growth conditions, while PsD5Des had the lowest expression level. The deduced amino acid sequences from all three genes contained three conserved histidine boxes and a cytochrome b(5) domain. Sequence alignment showed that the three genes were homologous to corresponding desaturases from other microalgae and fungi. The predicted activities of these three front-end desaturases leading to the synthesis of LC-PUFA were also confirmed in yeast and in higher plants. |
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