CHEBI:95073 - ricolinostat

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ChEBI Name ricolinostat
ChEBI ID CHEBI:95073
Definition A member of the class of pyrimidines that is pyrimidine substituted by diphenylamino and [7-(hydroxyamino)-7-oxoheptyl]aminocarbonyl groups at positions 2 and 5, respectively. It is a histone deacetylase 6 inhibitor with potential antineoplastic activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C24H27N5O3
Net Charge 0
Average Mass 433.512
Monoisotopic Mass 433.21139
InChI InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
InChIKey QGZYDVAGYRLSKP-UHFFFAOYSA-N
SMILES ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C1=CC=CC=C1)C1=CC=CC=C1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ricolinostat (CHEBI:95073) has role anti-inflammatory agent (CHEBI:67079)
ricolinostat (CHEBI:95073) has role antineoplastic agent (CHEBI:35610)
ricolinostat (CHEBI:95073) has role apoptosis inducer (CHEBI:68495)
ricolinostat (CHEBI:95073) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
ricolinostat (CHEBI:95073) is a hydroxamic acid (CHEBI:24650)
ricolinostat (CHEBI:95073) is a pyrimidinecarboxamide (CHEBI:48438)
ricolinostat (CHEBI:95073) is a secondary carboxamide (CHEBI:140325)
ricolinostat (CHEBI:95073) is a substituted aniline (CHEBI:48975)
ricolinostat (CHEBI:95073) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
INNs Sources
ricolinostat WHO MedNet
ricolinostat WHO MedNet
ricolinostat WHO MedNet
ricolinostatum WHO MedNet
Synonyms Sources
ACY 1215 ChEBI
ACY-1215 DrugBank
ACY-63 DrugBank
ACY1215 ChEBI
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide ChEBI
Manual Xrefs Databases
AH4 PDBeChem
D10661 KEGG DRUG
DB12376 DrugBank
HMDB0244543 HMDB
LSM-6324 LINCS
View more database links
Registry Number Type Source
1316214-52-4 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
21 June 2024