CHEBI:135775 - mosapramine

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ChEBI Name mosapramine
ChEBI ID CHEBI:135775
Definition A racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C28H35ClN4O
Net Charge 0
Average Mass 479.070
Monoisotopic Mass 478.24994
Roles Classification
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Application(s): second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
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ChEBI Ontology
Outgoing mosapramine (CHEBI:135775) has part (R)-mosapramine (CHEBI:166971)
mosapramine (CHEBI:135775) has part (S)-mosapramine (CHEBI:166970)
mosapramine (CHEBI:135775) has role dopaminergic antagonist (CHEBI:48561)
mosapramine (CHEBI:135775) has role second generation antipsychotic (CHEBI:65191)
mosapramine (CHEBI:135775) is a racemate (CHEBI:60911)
IUPAC Name
rac-1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
INNs Sources
mosapramina WHO MedNet
mosapramine WHO MedNet
mosapramine WHO MedNet
mosapraminum WHO MedNet
Synonyms Sources
(±)-mosapramine ChEBI
(RS)-mosapramine ChEBI
clospipramine DrugCentral
rac-mosapramine ChEBI
racemic mosapramine ChEBI
Y-516 DrugCentral
Manual Xrefs Databases
1847 DrugCentral
4107 ChemSpider
D08235 KEGG DRUG
DB13676 DrugBank
Mosapramine Wikipedia
View more database links
Registry Number Type Source
89419-40-9 CAS Registry Number ChemIDplus
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Last Modified
14 January 2021