Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.
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InChI=1S/C19H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21/h2-18H2,1H3,(H,20,21) |
ISYWECDDZWTKFF-UHFFFAOYSA-N |
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Ganoderma lucidum
(NCBI:txid5315)
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Found in
spore
(BTO:0001171).
See:
PubMed
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Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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fungal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
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View more via ChEBI Ontology
19:00
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ChEBI
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C19:0
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ChEBI
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n-nonadecanoic acid
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NIST Chemistry WebBook
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n-Nonadecanoic acid
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ChemIDplus
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nonadecylic acid
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ChEBI
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Nonadecylic acid
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KEGG COMPOUND
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1786261
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Reaxys Registry Number
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Reaxys
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646-30-0
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CAS Registry Number
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ChemIDplus
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646-30-0
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CAS Registry Number
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NIST Chemistry WebBook
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18827358
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PubMed citation
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Europe PMC
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19086541
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PubMed citation
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Europe PMC
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