tedisamil (CHEBI:134747)

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ChEBI Name	tedisamil

ChEBI ID	CHEBI:134747

Definition	A member of the class of diazabicyclononanes that is (1s,5s)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] in which the hydrogens at positions 3 and 7 are replaced by cyclopropylmethyl groups. It is a potassium channel blocker and an antiarrhythmic agent currently currently in development for the treatment of atrial fibrillation.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H32N2

Net Charge

Average Mass

288.479

Monoisotopic Mass

288.25655

InChI

InChI=1S/C19H32N2/c1-2-8-19(7-1)17-11-20(9-15-3-4-15)12-18(19)14-21(13-17)10-16-5-6-16/h15-18H,1-14H2/t17-,18+

InChIKey

CTIRHWCPXYGDGF-HDICACEKSA-N

SMILES

[H][C@]12CN(CC3CC3)C[C@]([H])(CN(CC3CC3)C1)C21CCCC1

Roles Classification
Biological Role(s):	potassium channel blocker An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.

Application(s):	anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.

ChEBI Ontology
Outgoing	tedisamil (CHEBI:134747) has role anti-arrhythmia drug (CHEBI:38070) tedisamil (CHEBI:134747) has role potassium channel blocker (CHEBI:50509) tedisamil (CHEBI:134747) is a azaspiro compound (CHEBI:35624) tedisamil (CHEBI:134747) is a cyclopentanes (CHEBI:23493) tedisamil (CHEBI:134747) is a cyclopropanes (CHEBI:51454) tedisamil (CHEBI:134747) is a diazabicyclononane (CHEBI:18945)

IUPAC Name

(1s,5s)-3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane]

Brand Name	Source
Pulzium	DrugBank

Registry Number	Type	Source
90961-53-8	CAS Registry Number	ChemIDplus

Last Modified

21 September 2020