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> Main
CHEBI:52724 - PS-519
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ChEBI Name
PS-519
ChEBI ID
CHEBI:52724
Definition
A β-lactone proteasome inhibitor derived from lactacystin.
Stars
This entity has been manually annotated by the ChEBI Team.
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Formula
C12H19NO4
Net Charge
0
Average Mass
241.28360
Monoisotopic Mass
241.13141
InChI
InChI=1S/C12H19NO4/c1-
4-
5-
7-
9-
12(11(16)
17-
9,13-
10(7)
15)
8(14)
6(2)
3/h6-
9,14H,4-
5H2,1-
3H3,(H,13,15)
/t7-
,8+,9+,12-
/m1/s1
InChIKey
KMXHEXRPYSXLRN-JDVQERKKSA-N
SMILES
CCC[C@@H]1[C@@H]2OC(=O)[C@@]2(NC1=O)[C@@H](O)C(C)C
Roles Classification
Application
(s):
proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
PS-519 (
CHEBI:52724
)
has functional parent
lactacystin (
CHEBI:52722
)
PS-519 (
CHEBI:52724
)
has role
proteasome inhibitor (
CHEBI:52726
)
PS-519 (
CHEBI:52724
)
is a
β-lactone (
CHEBI:49043
)
PS-519 (
CHEBI:52724
)
is a
lactam (
CHEBI:24995
)
IUPAC Name
(1
R
,4
R
,5
S
)-
1-
[(1S)-
1-
hydroxy-
2-
methylpropyl]-
4-
propyl-
6-
oxa-
2-
azabicyclo[3.2.0]heptane-
3,7-
dione
Registry Number
Type
Source
8492768
Beilstein Registry Number
Beilstein
Last Modified
08 July 2009