3-iodothyronamine (CHEBI:89700)

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ChEBI Name	3-iodothyronamine

ChEBI ID	CHEBI:89700

Definition	An organoiodine compound that is benzene substituted by 4-hydroxyphenoxy, iodo, and 2-aminoethyl groups at positions 1, 2, and 4, respectively. It is a thyroid hormone metabolite and a potent agonist of trace amine-associated receptor 1.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C14H14INO2

Net Charge

Average Mass

355.175

Monoisotopic Mass

355.00692

InChI

InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2

InChIKey

XIINYOJWNGOUPF-UHFFFAOYSA-N

SMILES

NCCC1=CC(I)=C(OC2=CC=C(O)C=C2)C=C1

Metabolite of Species	Details
Homo sapiens (NCBI:txid9606)	Found in blood serum (BTO:0000133blood serum). See: PubMed

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	trace amine-associated receptor 1 agonist An agonist that selectively binds to and activates trace amine-associated receptor 1. apoptosis inhibitor Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. anti-obesity agent Any substance which is used to reduce or control weight. human blood serum metabolite Any metabolite (endogenous or exogenous) found in human blood serum samples.

Application(s):	neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anti-inflammatory agent Any compound that has anti-inflammatory effects. cardioprotective agent Any protective agent that is able to prevent damage to the heart.

ChEBI Ontology
Outgoing	3-iodothyronamine (CHEBI:89700) has role anti-inflammatory agent (CHEBI:67079) 3-iodothyronamine (CHEBI:89700) has role anti-obesity agent (CHEBI:74518) 3-iodothyronamine (CHEBI:89700) has role apoptosis inhibitor (CHEBI:68494) 3-iodothyronamine (CHEBI:89700) has role cardioprotective agent (CHEBI:77307) 3-iodothyronamine (CHEBI:89700) has role human blood serum metabolite (CHEBI:85234) 3-iodothyronamine (CHEBI:89700) has role neuroprotective agent (CHEBI:63726) 3-iodothyronamine (CHEBI:89700) has role trace amine-associated receptor 1 agonist (CHEBI:228347) 3-iodothyronamine (CHEBI:89700) is a aromatic ether (CHEBI:35618) 3-iodothyronamine (CHEBI:89700) is a organoiodine compound (CHEBI:37142) 3-iodothyronamine (CHEBI:89700) is a phenols (CHEBI:33853) 3-iodothyronamine (CHEBI:89700) is a primary amino compound (CHEBI:50994) 3-iodothyronamine (CHEBI:89700) is conjugate base of 3-iodothyronamine(1+) (CHEBI:231647)

Incoming	3-iodothyronamine(1+) (CHEBI:231647) is conjugate acid of 3-iodothyronamine (CHEBI:89700)

IUPAC Name

4-[4-(2-aminoethyl)-2-iodophenoxy]phenol

Synonyms	Sources
3-T₁AM	ChEBI
3-T1AM	ChEBI
4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol	PDBeChem
T1AM	ChEBI
T₁AM	ChEBI

Registry Number	Type	Source
712349-95-6	CAS Registry Number	ChEBI

Last Modified

24 June 2024