CHEBI:167605 - 1,8-dihydroxynaphthalene-melanin

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ChEBI Name 1,8-dihydroxynaphthalene-melanin
ChEBI ID CHEBI:167605
Definition A melanin pigment produced by certain fungi. It plays important roles in UV protection, oxidative stress and pathogenesis. In Aspergillus fumigatus, it is used as a virulence factor and plays an important role in the survival of the fungus during unfavorable conditions both in vivo and in vitro, and protects it from the host immune system. The pigment is generally synthesised from the pentaketide pathway in which 1,8-dihydroxynaphthalene is the immediate precursor which is polymerized to 1,8-dihydroxynaphthalene-melanin by a laccase enzyme.
Stars This entity has been manually annotated by the ChEBI Team.
Metabolite of Species Details
Monosporascus cannonballus (NCBI:txid155416) See: PubMed
Ascochyta rabiei (NCBI:txid5454) See: PubMed
Passalora fulva (NCBI:txid5499) Found in cell suspension culture (BTO:0000221). See: PubMed
Exophiala dermatitidis (NCBI:txid5970) See: PubMed
Pseudocercospora griseola (NCBI:txid687962) See: PubMed
Aspergillus fumigatus (NCBI:txid746128) See: PubMed
Exophiala pisciphila (NCBI:txid86051) See: PubMed
Hortaea werneckii (NCBI:txid91943) See: PubMed
Neophaeotheca triangularis (NCBI:txid92988) See: PubMed
Trimmatostroma salinum (NCBI:txid92990) See: PubMed
Roles Classification
Biological Role(s): Aspergillus metabolite
Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus .
fungal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
virulence factor
Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host.
biological pigment
An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
(via melanins )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has functional parent naphthalene-1,8-diol (CHEBI:167604)
1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role Aspergillus metabolite (CHEBI:76956)
1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role fungal metabolite (CHEBI:76946)
1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role virulence factor (CHEBI:72316)
1,8-dihydroxynaphthalene-melanin (CHEBI:167605) is a melanins (CHEBI:25179)
1,8-dihydroxynaphthalene-melanin (CHEBI:167605) is a polyketide (CHEBI:26188)
Synonyms Sources
1,8-DHN-melanin ChEBI
1,8-dihydroxynaphthalene (DHN) melanin ChEBI
1,8-dihydroxynaphthalene (DHN)-melanin ChEBI
1,8-dihydroxynaphthalene melanin ChEBI
Citations Types Sources
11179356 PubMed citation Europe PMC
12788746 PubMed citation Europe PMC
15033240 PubMed citation Europe PMC
15212456 PubMed citation Europe PMC
19306112 PubMed citation Europe PMC
20473673 PubMed citation Europe PMC
22714980 PubMed citation Europe PMC
23998343 PubMed citation Europe PMC
24123270 PubMed citation Europe PMC
26467568 PubMed citation Europe PMC
30582052 PubMed citation Europe PMC
31116900 PubMed citation Europe PMC
32391495 PubMed citation Europe PMC
33463687 PubMed citation Europe PMC
Last Modified
04 March 2021
General Comment
2021-03-04 The structure of melanin in 1,8-dihydroxynaphthalene-melanin is unknown.