CHEBI:156296 - G-1

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ChEBI Name G-1
ChEBI ID CHEBI:156296
Definition An organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline substituted by 6-bromo-1,3-benzodioxol-5-yl and acetyl groups at positions 4 and 8, respectively (the 3aS,4R,9bR-stereoisomer). It is a potent and selective GPER1 agonist (Ki = 11 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sabrina Toro
Supplier Information ChemicalBook:CB1325944, eMolecules:1934826, ZINC000100001998
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Formula C21H18BrNO3
Net Charge 0
Average Mass 412.283
Monoisotopic Mass 411.04701
InChI InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1
InChIKey VHSVKVWHYFBIFJ-HKZYLEAXSA-N
SMILES [H][C@]12CC=C[C@@]1([H])C1=C(N[C@H]2C2=CC3=C(OCO3)C=C2Br)C=CC(=C1)C(C)=O
Roles Classification
Biological Role(s): microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
G-protein-coupled receptor agonist
An agonist that binds to and activates G-protein-coupled receptors
anti-obesity agent
Any substance which is used to reduce or control weight.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing G-1 (CHEBI:156296) has role anti-obesity agent (CHEBI:74518)
G-1 (CHEBI:156296) has role antihypertensive agent (CHEBI:35674)
G-1 (CHEBI:156296) has role antineoplastic agent (CHEBI:35610)
G-1 (CHEBI:156296) has role G-protein-coupled receptor agonist (CHEBI:70998)
G-1 (CHEBI:156296) has role microtubule-destabilising agent (CHEBI:61951)
G-1 (CHEBI:156296) is a aromatic ketone (CHEBI:76224)
G-1 (CHEBI:156296) is a benzodioxole (CHEBI:38733)
G-1 (CHEBI:156296) is a methyl ketone (CHEBI:51867)
G-1 (CHEBI:156296) is a organic heterotricyclic compound (CHEBI:26979)
G-1 (CHEBI:156296) is a organobromine compound (CHEBI:37141)
IUPAC Name
1-[(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
Synonyms Sources
G 1 ChEBI
G1 ChEBI
Registry Number Type Source
881639-98-1 CAS Registry Number SUBMITTER
Citations Types Sources
34943948 PubMed citation Europe PMC
36276488 PubMed citation Europe PMC
36430793 PubMed citation Europe PMC
38318490 PubMed citation Europe PMC
38701557 PubMed citation Europe PMC
38867416 PubMed citation Europe PMC
38928205 PubMed citation Europe PMC
Last Modified
10 September 2024