Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity. |
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InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20) |
LOBCDGHHHHGHFA-UHFFFAOYSA-N |
CCOC(=O)C1=C(C)NC(=S)NC1c1cccc(O)c1 |
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EC 3.5.1.5 (urease) inhibitor
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis.
antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
antimitotic
Any compound that inhibits cell division (mitosis).
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antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
rac-ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
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8495831
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Reaxys Registry Number
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Reaxys
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20519355
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PubMed citation
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Europe PMC
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23292345
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Europe PMC
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23727895
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Europe PMC
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25300040
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Europe PMC
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26035434
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Europe PMC
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27592117
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28314282
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28612296
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28683403
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30015883
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30108989
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Europe PMC
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30151081
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Europe PMC
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