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nigerloxin |
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CHEBI:133971 |
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A member of the class of benzoic acids that is benzoic acid which is substituted at positions 2, 3, 4, 5, and 6 by carbamoyl, hydroxy, E)-prop-1-en-1-yl, methyl, and methoxy groups, respectively. Obtained from solid-state fermentation of Aspergillus niger CFR-W-105, it inhibits soy bean lipoxygenase-1 (LOX-1) and rat lens aldose reductase (RLAR). It also shows free radical scavenging activity. |
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This entity has been manually annotated by the ChEBI Team.
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Julian Brandl
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ZINC000085560803 |
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Molfile
XML
SDF
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InChI=1S/C13H15NO5/c1-4-5-7-6(2)11(19-3)9(13(17)18)8(10(7)15)12(14)16/h4-5,15H,1-3H3,(H2,14,16)(H,17,18)/b5-4+ |
UOIRNFVLBXIGKH-SNAWJCMRSA-N |
C=1(C(=C(C(=C(C1O)/C=C/C)C)OC)C(O)=O)C(=O)N |
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Aspergillus niger
(NCBI:txid5061)
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of strain
CFR-W-105
See:
PubMed
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antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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Aspergillus metabolite
Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus .
EC 1.1.1.21 (aldehyde reductase) inhibitor
An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
lipoxygenase inhibitor
A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
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View more via ChEBI Ontology
2-carbamoyl-3-hydroxy-6-methoxy-5-methyl-4-[(1E)-prop-1-en-1-yl]benzoic acid
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9342829
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Reaxys Registry Number
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Reaxys
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12458767
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PubMed citation
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Europe PMC
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15134145
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PubMed citation
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Europe PMC
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19504138
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PubMed citation
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Europe PMC
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22423974
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PubMed citation
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Europe PMC
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23458199
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PubMed citation
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Europe PMC
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23767695
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PubMed citation
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Europe PMC
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24915992
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PubMed citation
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Europe PMC
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25507780
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PubMed citation
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Europe PMC
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