CHEBI:228345 - ZCAN262

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ChEBI Name ZCAN262 ChEBI ID CHEBI:228345 Definition A member of the class of pyrrolopyrazoles that is 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole substituted by 2,4-difluorobenzyl and 4-(dimethylcarbamoyl)pyrimidin-2-yl groups at positions 2 and 5, respectively. It targets the AMPA receptor GluA2 subunit and exhibits potent effects in restoring neurological function and myelination in mouse models for multiple sclerosis. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Formula C19H18F2N6O Net Charge 0 Average Mass 384.391 Monoisotopic Mass 384.15102 InChI InChI=1S/C19H18F2N6O/c1-25(2)18(28)16-5-6-22-19(23-16)26-8-13-10-27(24-17(13)11-26)9-12-3-4-14(20)7-15(12)21/h3-7,10H,8-9,11H2,1-2H3 InChIKey JYKQUGHLYOBLQZ-UHFFFAOYSA-N SMILES CN(C)C(=O)C1=NC(=NC=C1)N1CC2=CN(CC3=CC=C(F)C=C3F)N=C2C1 Roles Classification Biological Role(s): AMPA receptor antagonist An antagonist at the AMPA receptor. View more via ChEBI Ontology ChEBI Ontology Outgoing ZCAN262 (CHEBI:228345) has role AMPA receptor antagonist (CHEBI:71014) ZCAN262 (CHEBI:228345) is a difluorobenzene (CHEBI:38582) ZCAN262 (CHEBI:228345) is a pyrimidinecarboxamide (CHEBI:48438) ZCAN262 (CHEBI:228345) is a pyrrolopyrazole (CHEBI:46866) ZCAN262 (CHEBI:228345) is a tertiary carboxamide (CHEBI:140326) IUPAC Name 2-[2-(2,4-difluorobenzyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-N,N-dimethylpyrimidine-4-carboxamide Citation Type Source 38064562 PubMed citation Europe PMC Last Modified 22 December 2023