Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.
In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines.
|
Read full article at Wikipedia
|
InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3 |
MOYGZHXDRJNJEP-UHFFFAOYSA-N |
CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1 |
|
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
|
|
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
|
|
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
local anaesthetic
Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
|
|
View more via ChEBI Ontology
1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
|
buclizina
|
WHO MedNet
|
buclizine
|
WHO MedNet
|
buclizine
|
ChemIDplus
|
buclizinum
|
WHO MedNet
|
1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine
|
ChemIDplus
|
Buclizine
|
KEGG COMPOUND
|
349567
|
Reaxys Registry Number
|
Reaxys
|
82-95-1
|
CAS Registry Number
|
ChemIDplus
|
82-95-1
|
CAS Registry Number
|
NIST Chemistry WebBook
|
Mostafa GA, Al-Badr AA (2011) Buclizine. Profiles of drug substances, excipients, and related methodology 36, 1-33 [PubMed:22469258] [show Abstract] A comprehensive profile on buclizine hydrochloride, the piperazine derivative which is a sedating antihistamine with antimuscarinic and moderate sedative action and used mainly for its antiemetic effect in the prevention of motion sickness and migraine, is prepared. This profile contains the following sections: description, uses and applications, methods of preparation, physical characteristics, methods of analysis and stability. The physical characteristics section includes solubility, melting range, X-ray powder diffraction pattern, ultraviolet/visible spectroscopy, infrared spectroscopy, proton and carbon-13 nuclear magnetic resonance spectrometry, and mass spectrometry. Methods of analysis section includes compendial BP methods, spectrophotometry, potentiometry, and chromatography (TLC, GC, HPLC). | Silva P, Chaves CB, Magalhães CD, Loureiro LA, Soares DP, de Souza AM, Jones WA, Rocha SM (1968) [Effects of a buclizine and vitamin combination on appetite and body weight]. Hospital (Rio de Janeiro, Brazil) 74, 1273-1278 [PubMed:5304814] | Castelar E, De Melo G, Sales R, Goncalves A (1966) [Clinical findings on the hypoglucemic action of buclizine]. Prensa medica argentina 53, 700-703 [PubMed:4387177] | SETTEL E (1959) Buclizine, a new tranquilizing agent. Journal of the American Geriatrics Society 7, 67-70 [PubMed:13620483] | OLSON HJ, PETERSON JA, TYLER ET (1959) Buclizine and hydroxyzine as tranquilizing agents in infertility. Obstetrics and gynecology 14, 473-477 [PubMed:14428806] |
|