setiptiline (CHEBI:135076)

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ChEBI Name	setiptiline

ChEBI ID	CHEBI:135076

Definition	A tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H19N

Net Charge

Average Mass

261.368

Monoisotopic Mass

261.15175

InChI

InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3

InChIKey

GVPIXRLYKVFFMK-UHFFFAOYSA-N

SMILES

CN1CCC2=C(C1)C1=C(CC3=C2C=CC=C3)C=CC=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Application(s):	alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. (via tetracyclic antidepressant )

ChEBI Ontology
Outgoing	setiptiline (CHEBI:135076) has role α-adrenergic antagonist (CHEBI:37890) setiptiline (CHEBI:135076) has role serotonergic antagonist (CHEBI:48279) setiptiline (CHEBI:135076) is a tertiary amino compound (CHEBI:50996) setiptiline (CHEBI:135076) is a tetracyclic antidepressant (CHEBI:50940) setiptiline (CHEBI:135076) is conjugate base of setiptiline(1+) (CHEBI:176784)

Incoming	setiptiline(1+) (CHEBI:176784) is conjugate acid of setiptiline (CHEBI:135076)

IUPAC Name

2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine

Synonyms	Sources
2,3,4,9-tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine	ChemIDplus
MO 8282	ChemIDplus
MO-8282	DrugBank
Org 8282	DrugBank
Org-8282	DrugCentral
teciptilline	DrugCentral

Last Modified

09 July 2021