CHEBI:145206 - 12-hydroxynevirapine

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ChEBI Name 12-hydroxynevirapine ChEBI ID CHEBI:145206 Definition A dipyridodiazepine that is nevirapine in which one of the hydrogens of the methyl group has been substituted by a hydroxy group. It is a metabolite of the anti-HIV drug, nevirapine. Stars This entity has been manually annotated by the ChEBI Team. Submitter Mark Williams Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Formula C15H14N4O2 Net Charge 0 Average Mass 282.303 Monoisotopic Mass 282.11168 InChI InChI=1S/C15H14N4O2/c20-8-9-5-7-17-14-12(9)18-15(21)11-2-1-6-16-13(11)19(14)10-3-4-10/h1-2,5-7,10,20H,3-4,8H2,(H,18,21) InChIKey SEBABOMFNCVZGF-UHFFFAOYSA-N SMILES O=C1NC=2C(N(C3CC3)C=4N=CC=CC41)=NC=CC2CO Metabolite of Species Details Homo sapiens (NCBI:txid9606) Found in blood plasma (BTO_0000131). See: PubMed Roles Classification Biological Role(s): drug metabolite View more via ChEBI Ontology ChEBI Ontology Outgoing 12-hydroxynevirapine (CHEBI:145206) has functional parent nevirapine (CHEBI:63613) 12-hydroxynevirapine (CHEBI:145206) has role drug metabolite (CHEBI:49103) 12-hydroxynevirapine (CHEBI:145206) is a aromatic primary alcohol (CHEBI:33857) 12-hydroxynevirapine (CHEBI:145206) is a cyclopropanes (CHEBI:51454) 12-hydroxynevirapine (CHEBI:145206) is a dipyridodiazepine (CHEBI:63667) IUPAC Name 11-cyclopropyl-4-(hydroxymethyl)-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one Synonyms Sources 11-cyclopropyl-4-(hydroxymethyl)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one ChEBI 12-hydroxy-nevirapine ChEBI 12-hydroxy-NVP ChEBI 12-OH-NVP ChEBI N11-cyclopropyl-4-hydroxymethyl-5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)(1,4)diazepin-6-one ChemIDplus Manual Xref Database HMDB0013911 HMDB View more database links Registry Number Type Source 133627-24-4 CAS Registry Number ChemIDplus Citations Types Sources 10421616 PubMed citation Europe PMC 17618842 PubMed citation Europe PMC 18042504 PubMed citation Europe PMC 18597499 PubMed citation Europe PMC 20392079 PubMed citation Europe PMC 23459477 PubMed citation Europe PMC 23590230 PubMed citation Europe PMC 23947594 PubMed citation Europe PMC 24051761 PubMed citation Europe PMC 25275777 PubMed citation Europe PMC 25394082 PubMed citation Europe PMC 26620700 PubMed citation Europe PMC 29309900 PubMed citation Europe PMC 30028994 PubMed citation Europe PMC Last Modified 12 November 2019