CHEBI:194213 - Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg

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ChEBI Name Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg
ChEBI ID CHEBI:194213
Definition An oligopeptide comprising of L-threonine, L-proline, L-proline, L-alanine, glycine, L-proline, L-aspartic acid, L-valine, glycine, L-proline, and L-arginine amino acids joined in sequence by peptide linkages. It is isolated from the venoms of three species of New World pit vipers from the subfamily, Crotalinae.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Mark Williams
Supplier Information
Download Molfile XML SDF
Formula C46H74N14O15
Net Charge 0
Average Mass 1063.181
Monoisotopic Mass 1062.54581
InChI InChI=1S/C46H74N14O15/c1-23(2)36(42(71)52-22-33(63)57-16-6-11-28(57)40(69)54-26(45(74)75)10-5-15-50-46(48)49)56-38(67)27(20-34(64)65)55-41(70)29-12-7-17-58(29)32(62)21-51-37(66)24(3)53-39(68)30-13-8-18-59(30)43(72)31-14-9-19-60(31)44(73)35(47)25(4)61/h23-31,35-36,61H,5-22,47H2,1-4H3,(H,51,66)(H,52,71)(H,53,68)(H,54,69)(H,55,70)(H,56,67)(H,64,65)(H,74,75)(H4,48,49,50)/t24-,25+,26-,27-,28-,29-,30-,31-,35-,36-/m0/s1
InChIKey MGUYOORQEGDWEH-WDZUUAOZSA-N
SMILES CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Metabolite of Species Details
Agkistrodon bilineatus (NCBI:txid8718) Found in venom (BTO:0001439). See: PubMed
Crotalus viridis viridis (NCBI:txid8742) Found in venom (BTO:0001439). See: PubMed
Lachesis muta (NCBI:txid8752) Found in venom (BTO:0001439). See: PubMed
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): bradykinin receptor antagonist
An antagonist at the bradykinin receptor.
animal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
venom
A toxin used by animals and injected into their victims by a bite or sting.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg (CHEBI:194213) has role animal metabolite (CHEBI:75767)
Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg (CHEBI:194213) has role bradykinin receptor antagonist (CHEBI:68557)
Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg (CHEBI:194213) has role venom (CHEBI:78505)
Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg (CHEBI:194213) is a oligopeptide (CHEBI:25676)
IUPAC Name
L-threonyl-L-prolyl-L-prolyl-L-alanylglycyl-L-prolyl-L-α-aspartyl-L-valylglycyl-L-prolyl-L-arginine
Synonyms Sources
H-Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg-OH ChEBI
L-Thr-L-Pro-L-Pro-L-Ala-Gly-L-Pro-L-Asp-L-Val-Gly-L-Pro-L-Arg ChEBI
T-P-P-A-G-P-D-V-G-P-R ChEBI
Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg-OH ChEBI
TPPAGPDVGPR ChEBI
Registry Number Type Source
873083-34-2 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
16277978 PubMed citation Europe PMC
16979945 PubMed citation Europe PMC
20503934 PubMed citation Europe PMC
Last Modified
18 January 2023