azosemide (CHEBI:31248)

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ChEBI Name	azosemide

ChEBI ID	CHEBI:31248

Definition	A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C12H11ClN6O2S2

Net Charge

Average Mass

370.83800

Monoisotopic Mass

370.00734

InChI

InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

InChIKey

HMEDEBAJARCKCT-UHFFFAOYSA-N

SMILES

NS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl

Roles Classification
Application(s):	loop diuretic A diuretic that acts on the ascending loop of Henle in the kidney.

ChEBI Ontology
Outgoing	azosemide (CHEBI:31248) has role loop diuretic (CHEBI:77608) azosemide (CHEBI:31248) is a monochlorobenzenes (CHEBI:83403) azosemide (CHEBI:31248) is a sulfonamide (CHEBI:35358) azosemide (CHEBI:31248) is a tetrazoles (CHEBI:35689) azosemide (CHEBI:31248) is a thiophenes (CHEBI:26961)

IUPAC Name

2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide

Synonyms	Sources
2-chloro-5-(1H-tetrazol-5-yl)-N⁴-2-thenylsulfanilamide	ChemIDplus
5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole	ChemIDplus
Diart	KEGG DRUG

Last Modified

22 February 2017