CHEBI:59524 - lipoarabinomannan

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ChEBI Name lipoarabinomannan
ChEBI ID CHEBI:59524
Definition A glycolipid comprising a glycosylphosphatidyl-myo-inositol-anchored lipoglycan; a virulence factor associated with Mycobacterium tuberculosis.
Stars This entity has been manually annotated by the ChEBI Team.
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Lipoarabinomannan, also called LAM, is a glycolipid, and a virulence factor associated with Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. Its primary function is to inactivate macrophages and scavenge oxidative radicals. The inactivation of macrophages allows for the dissemination of mycobacteria to other parts of the body. The destruction of oxidative radicals allows for the survival of the bacteria, as oxidative free radicals are an important mechanism by which our bodies try to rid ourselves of infection.
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Roles Classification
Biological Role(s): antigen
Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
virulence factor
Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host.
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ChEBI Ontology
Outgoing lipoarabinomannan (CHEBI:59524) has role antigen (CHEBI:59132)
lipoarabinomannan (CHEBI:59524) has role virulence factor (CHEBI:72316)
lipoarabinomannan (CHEBI:59524) is a glycosylphosphatidylinositol (CHEBI:24410)
Synonyms Sources
LAM ChEBI
LAMs ChEBI
lipoarabinomannans ChEBI
Manual Xref Database
Lipoarabinomannan Wikipedia
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Last Modified
29 July 2019