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> Main
CHEBI:62882 - IWR-1-
endo
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ChEBI Ontology
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ChEBI Name
IWR-1-
endo
ChEBI ID
CHEBI:62882
ChEBI ASCII Name
IWR-1-endo
Definition
A dicarboximide having an
endo
bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group.
Stars
This entity has been manually annotated by the ChEBI Team.
Submitter
Margaret Duesbury
Supplier Information
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Molfile
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Molfile
Molfile
Formula
C25H19N3O3
Net Charge
0
Average Mass
409.438
Monoisotopic Mass
409.14264
InChI
InChI=1S/C25H19N3O3/c29-
23(27-
19-
5-
1-
3-
14-
4-
2-
12-
26-
22(14)
19)
15-
8-
10-
18(11-
9-
15)
28-
24(30)
20-
16-
6-
7-
17(13-
16)
21(20)
25(28)
31/h1-
12,16-
17,20-
21H,13H2,(H,27,29)
/t16-
,17+,20-
,21+
InChIKey
ZGSXEXBYLJIOGF-ALFLXDJESA-N
SMILES
[C@@]12([C@H]3C=C[C@@H]([C@]1(C(N(C2=O)C=4C=CC(=CC4)C(NC=5C6=C(C=CC5)C=CC=N6)=O)=O)[H])C3)[H]
Roles Classification
Biological Role
(s):
Wnt signalling inhibitor
A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
axin stabilizer
Any compound that stabilizes axin proteins.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
IWR-1-
endo
(
CHEBI:62882
)
has role
axin stabilizer (
CHEBI:62914
)
IWR-1-
endo
(
CHEBI:62882
)
has role
Wnt signalling inhibitor (
CHEBI:78031
)
IWR-1-
endo
(
CHEBI:62882
)
is a
benzamides (
CHEBI:22702
)
IWR-1-
endo
(
CHEBI:62882
)
is a
bridged compound (
CHEBI:35990
)
IWR-1-
endo
(
CHEBI:62882
)
is a
dicarboximide (
CHEBI:35356
)
IWR-1-
endo
(
CHEBI:62882
)
is a
quinolines (
CHEBI:26513
)
IUPAC Name
4-
[(3a
R
,4
S
,7
R
,7a
S
)-
1,3-
dioxo-
1,3,3a,4,7,7a-
hexahydro-
2
H
-
4,7-
methanoisoindol-
2-
yl]-
N
-
(quinolin-
8-
yl)benzamide
Synonym
Source
IRW1
SUBMITTER
Manual Xrefs
Databases
LSM-5707
LINCS
WO2009155001
Patent
View more database links
Registry Number
Type
Source
19908763
Reaxys Registry Number
Reaxys
Citations
Types
Sources
19125156
PubMed citation
SUBMITTER
19410457
PubMed citation
Europe PMC
19759537
PubMed citation
SUBMITTER
25963533
PubMed citation
Europe PMC
26141761
PubMed citation
Europe PMC
26214410
PubMed citation
Europe PMC
26549292
PubMed citation
Europe PMC
Last Modified
06 July 2016