An organic sodium salt that is the heptahydrate form of pemetrexed disodium. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Stars
This entity has been manually annotated by the ChEBI Team.
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of phosphoribosylglycinamide formyltransferase (EC 2.1.2.2).
pemetrexed disodium heptahydrate
(CHEBI:63723)
has part
pemetrexed disodium
(CHEBI:63722)
pemetrexed disodium heptahydrate
(CHEBI:63723)
has role
antimetabolite
(CHEBI:35221)
pemetrexed disodium heptahydrate
(CHEBI:63723)
has role
antineoplastic agent
(CHEBI:35610)
pemetrexed disodium heptahydrate
(CHEBI:63723)
has role
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
(CHEBI:50683)
pemetrexed disodium heptahydrate
(CHEBI:63723)
has role
EC 2.1.1.45 (thymidylate synthase) inhibitor
(CHEBI:63720)
pemetrexed disodium heptahydrate
(CHEBI:63723)
has role
EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
(CHEBI:63721)
pemetrexed disodium heptahydrate
(CHEBI:63723)
is a
hydrate
(CHEBI:35505)
pemetrexed disodium heptahydrate
(CHEBI:63723)
is a
organic sodium salt
(CHEBI:38700)