A peptide and carboxamide that is L-leucyl-L-phenylalaninamide, L-Leu-L-Phe-NH2, which has been acylated on the N-terminus by a Phe-Phe hydroxyethylene dipeptide isotere, 2R-benzyl-5S-tert-butoxycarbonylamino-4R-hydroxy-6-phenylhexanoic acid. Compounds based on the structure of L-685,458 are potent inhibitors of γ-secretase, which mediates the final catalytic step that generates the amyloid β-peptide (Aβ), which assembles into the neurotoxic aggregates in the brains of sufferers of Alzheimer's disease.
Stars
This entity has been manually annotated by the ChEBI Team.