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ChEBI
> Main
CHEBI:77572 - tranilast
Main
ChEBI Ontology
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ChEBI Name
tranilast
ChEBI ID
CHEBI:77572
Definition
An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Read full article at Wikipedia
Formula
C18H17NO5
Net Charge
0
Average Mass
327.33130
Monoisotopic Mass
327.11067
InChI
InChI=1S/C18H17NO5/c1-
23-
15-
9-
7-
12(11-
16(15)
24-
2)
8-
10-
17(20)
19-
14-
6-
4-
3-
5-
13(14)
18(21)
22/h3-
11H,1-
2H3,(H,19,20)
(H,21,22)
/b10-
8+
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
SMILES
COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
Roles Classification
Chemical Role
(s):
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Br
o
nsted base).
(via
oxoacid
)
Biological Role
(s):
calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
aryl hydrocarbon receptor agonist
An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
Application
(s):
nephroprotective agent
Any protective agent that is able to prevent damage to the kidney.
anti-allergic agent
A drug used to treat allergic reactions.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
hepatoprotective agent
Any compound that is able to prevent damage to the liver.
anti-asthmatic drug
A drug used to treat asthma.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
tranilast (
CHEBI:77572
)
has functional parent
anthranilic acid (
CHEBI:30754
)
tranilast (
CHEBI:77572
)
has role
anti-allergic agent (
CHEBI:50857
)
tranilast (
CHEBI:77572
)
has role
anti-asthmatic drug (
CHEBI:49167
)
tranilast (
CHEBI:77572
)
has role
antineoplastic agent (
CHEBI:35610
)
tranilast (
CHEBI:77572
)
has role
aryl hydrocarbon receptor agonist (
CHEBI:72768
)
tranilast (
CHEBI:77572
)
has role
calcium channel blocker (
CHEBI:38215
)
tranilast (
CHEBI:77572
)
has role
hepatoprotective agent (
CHEBI:62868
)
tranilast (
CHEBI:77572
)
has role
nephroprotective agent (
CHEBI:76595
)
tranilast (
CHEBI:77572
)
is a
amidobenzoic acid (
CHEBI:48470
)
tranilast (
CHEBI:77572
)
is a
cinnamamides (
CHEBI:23247
)
tranilast (
CHEBI:77572
)
is a
dimethoxybenzene (
CHEBI:51681
)
tranilast (
CHEBI:77572
)
is a
secondary carboxamide (
CHEBI:140325
)
IUPAC Name
2-{[(2
E
)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
INNs
Sources
tranilast
WHO MedNet
tranilast
WHO MedNet
tranilast
KEGG DRUG
tranilastum
ChemIDplus
Synonyms
Sources
MK 341
ChemIDplus
MK-341
ChemIDplus
N-(3,4-Dimethoxycinnamoyl)anthranilic acid
ChemIDplus
Brand Name
Source
Rizaben
KEGG DRUG
Manual Xrefs
Databases
2714
DrugCentral
D02027
KEGG DRUG
D27
PDBeChem
Tranilast
Wikipedia
View more database links
Registry Numbers
Types
Sources
3085768
Reaxys Registry Number
Reaxys
53902-12-8
CAS Registry Number
KEGG DRUG
53902-12-8
CAS Registry Number
ChemIDplus
Citations
Types
Sources
22753703
PubMed citation
Europe PMC
23121382
PubMed citation
Europe PMC
23273396
PubMed citation
Europe PMC
23363021
PubMed citation
Europe PMC
23679559
PubMed citation
Europe PMC
23694807
PubMed citation
Europe PMC
23715805
PubMed citation
Europe PMC
23821545
PubMed citation
Europe PMC
23977380
PubMed citation
Europe PMC
24055688
PubMed citation
Europe PMC
24092987
PubMed citation
Europe PMC
24143895
PubMed citation
Europe PMC
24157455
PubMed citation
Europe PMC
24374452
PubMed citation
Europe PMC
24377619
PubMed citation
Europe PMC
24384948
PubMed citation
Europe PMC
24389486
PubMed citation
Europe PMC
24389817
PubMed citation
Europe PMC
24420060
PubMed citation
Europe PMC
24448965
PubMed citation
Europe PMC
24475260
PubMed citation
Europe PMC
24476069
PubMed citation
Europe PMC
Last Modified
07 March 2018