4-Hydroxy-estazolam (CHEBI:178137)

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This entity has been annotated by a third party. If you would like more information added to this entry, please contact ChEBI via email or GitHub.

ChEBI Name	4-Hydroxy-estazolam

ChEBI ID	CHEBI:178137

Stars	This entity has been manually annotated by a third party.

Submitter	MetaboLights

Supplier Information

Download	Molfile XML SDF

Formula

C16H11ClN4O

Net Charge

Average Mass

310.740

Monoisotopic Mass

310.06214

InChI

InChI=1S/C16H11ClN4O/c17-11-6-7-13-12(8-11)14(10-4-2-1-3-5-10)19-16(22)15-20-18-9-21(13)15/h1-9,16,22H

InChIKey

LJIJJCXFWLORDQ-UHFFFAOYSA-N

SMILES

ClC1=CC2=C(N3C(=NN=C3)C(O)N=C2C4=CC=CC=C4)C=C1

Metabolite of Species	Details
Arisaema erubescens (NCBI:txid228806)	Found in bulb (BTO:0000159). See: MetaboLights Study

Roles Classification
Biological Role(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

Application(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

ChEBI Ontology
Outgoing	4-Hydroxy-estazolam (CHEBI:178137) is a triazolobenzodiazepine (CHEBI:35501)

IUPAC Name

8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol