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InChI=1S/CH4O/c1-2/h2H,1H3
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ChEBI
> Main
CHEBI:53795 - (
R
)-amlodipine
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ChEBI Ontology
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ChEBI Name
(
R
)-amlodipine
ChEBI ID
CHEBI:53795
ChEBI ASCII Name
(R)-amlodipine
Definition
The (4
R
)-enantiomer of amlodipine.
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Molfile
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Molfile
Formula
C20H25ClN2O5
Net Charge
0
Average Mass
408.87600
Monoisotopic Mass
408.14520
InChI
InChI=1S/C20H25ClN2O5/c1-
4-
28-
20(25)
18-
15(11-
27-
10-
9-
22)
23-
12(2)
16(19(24)
26-
3)
17(18)
13-
7-
5-
6-
8-
14(13)
21/h5-
8,17,23H,4,9-
11,22H2,1-
3H3/t17-
/m1/s1
InChIKey
HTIQEAQVCYTUBX-QGZVFWFLSA-N
SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C([C@H]1c1ccccc1Cl)C(=O)OC
Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
(via
amlodipine
)
Application
(s):
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
(via
amlodipine
)
vasodilator agent
A drug used to cause dilation of the blood vessels.
(via
amlodipine
)
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
(
R
)-amlodipine (
CHEBI:53795
)
is a
amlodipine (
CHEBI:2668
)
(
R
)-amlodipine (
CHEBI:53795
)
is enantiomer of
(
S
)-amlodipine (
CHEBI:53796
)
Incoming
(
S
)-amlodipine (
CHEBI:53796
)
is enantiomer of
(
R
)-amlodipine (
CHEBI:53795
)
IUPAC Name
3-
ethyl 5-
methyl (4
R
)-
2-
[(2-
aminoethoxy)methyl]-
4-
(2-
chlorophenyl)-
6-
methyl-
1,4-
dihydropyridine-
3,5-
dicarboxylate
Registry Number
Type
Source
5857142
Reaxys Registry Number
Reaxys
Last Modified
24 August 2012