Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions. It is taken by mouth.
The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening. Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen.
Danazol was discovered in 1963 and was introduced for medical use in 1971. Due to their improved side-effect profiles, particularly their lack of masculinizing side effects, danazol has largely been replaced by gonadotropin-releasing hormone analogues (GnRH analogues) in the treatment of endometriosis. |
Read full article at Wikipedia
|
InChI=1S/C22H27NO2/c1- 4- 22(24) 10- 8- 18- 16- 6- 5- 15- 11- 19- 14(13- 23- 25- 19) 12- 20(15,2) 17(16) 7- 9- 21(18,22) 3/h1,11,13,16- 18,24H,5- 10,12H2,2- 3H3/t16- ,17+,18+,20+,21+,22+/m1/s1 |
POZRVZJJTULAOH-LHZXLZLDSA-N |
[H][C@@]12CCC3=Cc4oncc4C[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)C#C |
|
estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
|
|
anti-estrogen
A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
|
|
View more via ChEBI Ontology
[1,2]oxazolo[4',5':2,3]-17α-pregn-4-en-20-yn-17-ol
|
danazol
|
KEGG DRUG
|
danazolum
|
ChemIDplus
|
Cyclomen
|
DrugBank
|
Danocrine
|
DrugBank
|
26436
|
ChemSpider
|
779
|
DrugCentral
|
D00289
|
KEGG DRUG
|
Danazol
|
Wikipedia
|
DB01406
|
DrugBank
|
GB905844
|
Patent
|
US3135743
|
Patent
|
View more database links |
17230-88-5
|
CAS Registry Number
|
ChemIDplus
|
4851114
|
Beilstein Registry Number
|
Beilstein
|
|