InChI=1S/C20H22O3/c1-23-20-15-17(12-14-19(20)22)9-5-6-10-18(21)13-11-16-7-3-2-4-8-16/h2-4,6-8,10,12,14-15,22H,5,9,11,13H2,1H3/b10-6+ |
NOHMOWQGVDSLNY-UXBLZVDNSA-N |
COc1cc(CC\C=C\C(=O)CCc2ccccc2)ccc1O |
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Alpinia officinarum
(NCBI:txid199623)
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Found in
rhizome
(BTO:0001181).
See:
PubMed
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Alpinia officinarum
(NCBI:txid199623)
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Found in
root
(BTO:0001188).
See:
PubMed
|
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
(4E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one
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5445787
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Reaxys Registry Number
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Reaxys
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79559-60-7
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CAS Registry Number
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ChemIDplus
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Sun Y, Tabata K, Matsubara H, Kitanaka S, Suzuki T, Yasukawa K (2008) New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum. Planta medica 74, 427-431 [PubMed:18484537] [show Abstract] Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC (50) values of 0.83, 0.23 and 0.11 microM, respectively. |
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