InChI=1S/C20H28O2/c1-13(2)15-10-14-6-7-18-19(3,4)8-5-9-20(18,12-21)16(14)11-17(15)22/h10-13,18,22H,5-9H2,1-4H3/t18-,20-/m0/s1 |
YPWYNONCSGZEQQ-ICSRJNTNSA-N |
CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C=O)c2cc1O |
|
Fraxinus sieboldiana
(NCBI:txid490850)
|
Found in
stem
(BTO:0001300).
Previous component: stem bark; EtOAc soluble fraction of 95% ethanolic extract of air-dried stem bark
See:
PubMed
|
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
|
|
View more via ChEBI Ontology
12-hydroxyabieta-8,11,13-trien-20-al
|
6516788
|
Reaxys Registry Number
|
Reaxys
|
Lin S, Zhang Y, Liu M, Yang S, Gan M, Zi J, Song W, Fan X, Wang S, Liu Y, Yang Y, Chen X, Guo Y, Wang W, Shi J (2010) Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. Journal of natural products 73, 1914-1921 [PubMed:20961093] [show Abstract] Fourteen new abietane (1-14) and seven new C(20)-norabietane (15-21) diterpenes, together with five known analogues, have been isolated from the stem bark of Fraxinus sieboldiana. Their structures were elucidated by spectroscopic data analysis. In the in vitro assays, at 10(-5) M, compounds 8, 16, and 22 showed inhibitory activity against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with 59.7 ± 4.8%, 56.1 ± 5.6%, and 65.9 ± 3.1% inhibition, respectively. Compound 23 was active against H5N1 avian influenza virus with an IC(50) value of 4.8 μM. Compounds 3 and 5 exhibited selective cytotoxic activities against A2780 (IC(50) 1.7 μM) and A549 (IC(50) 6.0 μM), respectively. |
|