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(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone |
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CHEBI:70655 |
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(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone |
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A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and methyl groups at positions 3' and 5'. Isolated from the buds of Cleistocalyx operculatus, it has been shown to exhibit inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. |
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![](images/goldenstar.gif) ![](images/goldenstar.gif)
This entity has been manually annotated by the ChEBI Team.
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Molfile
XML
SDF
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InChI=1S/C18H18O5/c1- 10- 16(21) 11(2) 18(23- 3) 15(17(10) 22) 14(20) 9- 6- 12- 4- 7- 13(19) 8- 5- 12/h4- 9,19,21- 22H,1- 3H3/b9- 6+ |
HTDSMOBGCNRBHQ-RMKNXTFCSA-N |
COc1c(C)c(O)c(C)c(O)c1C(=O)\C=C\c1ccc(O)cc1 |
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Cleistocalyx operculatus
(IPNI:82151-3)
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Found in
flower bud
(BTO:0000470).
Combined methanolic extract of dried buds
See:
DOI
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plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
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EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
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View more via ChEBI Ontology
Outgoing
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(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
has functional parent
trans-chalcone
(CHEBI:48965)
(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
has role
EC 3.2.1.18 (exo-α-sialidase) inhibitor
(CHEBI:52425)
(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
has role
plant metabolite
(CHEBI:76924)
(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
is a
chalcones
(CHEBI:23086)
(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
is a
monomethoxybenzene
(CHEBI:25235)
(E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
(CHEBI:70655)
is a
polyphenol
(CHEBI:26195)
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(2E)-1-(2,4-dihydroxy-6-methoxy-3,5-dimethylphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
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21040404
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Reaxys Registry Number
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Reaxys
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20886838
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PubMed citation
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Europe PMC
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