splitomicin (CHEBI:75272)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	splitomicin

ChEBI ID	CHEBI:75272

Definition	A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C13H10O2

Net Charge

Average Mass

198.21730

Monoisotopic Mass

198.06808

InChI

InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2

InChIKey

ISFPDBUKMJDAJH-UHFFFAOYSA-N

SMILES

O=C1CCc2c(O1)ccc1ccccc21

Roles Classification
Biological Role(s):	Sir2 inhibitor An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2.

Application(s):	platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

ChEBI Ontology
Outgoing	splitomicin (CHEBI:75272) has role platelet aggregation inhibitor (CHEBI:50427) splitomicin (CHEBI:75272) has role Sir2 inhibitor (CHEBI:71181) splitomicin (CHEBI:75272) is a δ-lactone (CHEBI:18946) splitomicin (CHEBI:75272) is a benzochromenone (CHEBI:64986) splitomicin (CHEBI:75272) is a naphtho-α-pyrone (CHEBI:146280)

IUPAC Name

1,2-dihydro-3H-benzo[f]chromen-3-one

Synonym	Source
1,2-dihydro-3H-naphtho[2,1-b]-pyran-3-one	ChEBI

Registry Number	Type	Source
161649	Reaxys Registry Number	Reaxys

Last Modified

09 March 2020