CHEBI:91451 - CHIR-265

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ChEBI Name CHIR-265
ChEBI ID CHEBI:91451
Definition A member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C24H16F6N6O
Net Charge 0
Average Mass 518.423
Monoisotopic Mass 518.12898
InChI InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
InChIKey YABJJWZLRMPFSI-UHFFFAOYSA-N
SMILES CN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC2=C1C=CC(OC1=CC(=NC=C1)C1=NC=C(N1)C(F)(F)F)=C2
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
antiviral agent
A substance that destroys or inhibits replication of viruses.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
B-Raf inhibitor
A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing CHIR-265 (CHEBI:91451) has role angiogenesis inhibitor (CHEBI:48422)
CHIR-265 (CHEBI:91451) has role antineoplastic agent (CHEBI:35610)
CHIR-265 (CHEBI:91451) has role antiviral agent (CHEBI:22587)
CHIR-265 (CHEBI:91451) has role apoptosis inducer (CHEBI:68495)
CHIR-265 (CHEBI:91451) has role B-Raf inhibitor (CHEBI:75047)
CHIR-265 (CHEBI:91451) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
CHIR-265 (CHEBI:91451) is a (trifluoromethyl)benzenes (CHEBI:83565)
CHIR-265 (CHEBI:91451) is a aromatic ether (CHEBI:35618)
CHIR-265 (CHEBI:91451) is a benzimidazoles (CHEBI:22715)
CHIR-265 (CHEBI:91451) is a imidazoles (CHEBI:24780)
CHIR-265 (CHEBI:91451) is a organofluorine compound (CHEBI:37143)
CHIR-265 (CHEBI:91451) is a pyridines (CHEBI:26421)
CHIR-265 (CHEBI:91451) is a substituted aniline (CHEBI:48975)
IUPAC Name
1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Synonyms Sources
CHIR 265 ChEBI
CHIR265 ChEBI
RAF 265 ChEBI
RAF-265 ChEBI
RAF265 ChEBI
Manual Xrefs Databases
55J PDBeChem
LSM-1207 LINCS
WO2011044072 Patent
View more database links
Registry Number Type Source
927880-90-8 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
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Last Modified
20 June 2024