InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 |
PMATZTZNYRCHOR-CGLBZJNRSA-N |
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |
|
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
|
|
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
carcinogenic agent
A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16).
|
|
antirheumatic drug
A drug used to treat rheumatoid arthritis.
dermatologic drug
A drug used to treat or prevent skin disorders or for the routine care of skin.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
anti-asthmatic drug
A drug used to treat asthma.
|
|
View more via ChEBI Ontology
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
|
ciclosporin
|
KEGG DRUG
|
ciclosporina
|
ChemIDplus
|
ciclosporine
|
ChemIDplus
|
ciclosporinum
|
ChemIDplus
|
(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
|
ChEBI
|
1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
|
JCBN
|
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
|
ChEBI
|
Antibiotic S 7481F1
|
ChemIDplus
|
Ciclosporin
|
KEGG COMPOUND
|
Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
|
ChemIDplus
|
Cyclosporin A
|
KEGG COMPOUND
|
cyclosporin A
|
UniProt
|
Cyclosporine
|
KEGG COMPOUND
|
Cyclosporine
|
ChemIDplus
|
Gengraf
|
DrugBank
|
Neoral
|
DrugBank
|
Sandimmune
|
DrugBank
|
1765
|
VSDB
|
4447449
|
ChemSpider
|
760
|
DrugCentral
|
C00001517
|
KNApSAcK
|
C05086
|
KEGG COMPOUND
|
Ciclosporin
|
Wikipedia
|
CPD-20532
|
MetaCyc
|
D00184
|
KEGG DRUG
|
DB00091
|
DrugBank
|
HMDB0250682
|
HMDB
|
LMPK14000003
|
LIPID MAPS
|
LSM-1703
|
LINCS
|
US4117118
|
Patent
|
View more database links |
3647785
|
Reaxys Registry Number
|
Reaxys
|
59865-13-3
|
CAS Registry Number
|
ChemIDplus
|
11058832
|
PubMed citation
|
Europe PMC
|
11069928
|
PubMed citation
|
Europe PMC
|
11079273
|
PubMed citation
|
Europe PMC
|
11080188
|
PubMed citation
|
Europe PMC
|
11238591
|
PubMed citation
|
Europe PMC
|
11256490
|
PubMed citation
|
Europe PMC
|
11278005
|
PubMed citation
|
Europe PMC
|
11315347
|
PubMed citation
|
Europe PMC
|
11370709
|
PubMed citation
|
Europe PMC
|
11406057
|
PubMed citation
|
Europe PMC
|
11426833
|
PubMed citation
|
Europe PMC
|
11442023
|
PubMed citation
|
Europe PMC
|
11481617
|
PubMed citation
|
Europe PMC
|
11493684
|
PubMed citation
|
Europe PMC
|
11529914
|
PubMed citation
|
Europe PMC
|
11557554
|
PubMed citation
|
Europe PMC
|
11564166
|
PubMed citation
|
Europe PMC
|
11676831
|
PubMed citation
|
Europe PMC
|
11870366
|
PubMed citation
|
Europe PMC
|
12021257
|
PubMed citation
|
Europe PMC
|
12050171
|
PubMed citation
|
Europe PMC
|
12603598
|
PubMed citation
|
Europe PMC
|
12761440
|
PubMed citation
|
Europe PMC
|
12929192
|
PubMed citation
|
Europe PMC
|
12950728
|
PubMed citation
|
Europe PMC
|
14521916
|
PubMed citation
|
Europe PMC
|
14621732
|
PubMed citation
|
Europe PMC
|
14638917
|
PubMed citation
|
Europe PMC
|
14672695
|
PubMed citation
|
Europe PMC
|
14682659
|
PubMed citation
|
Europe PMC
|
14743390
|
PubMed citation
|
Europe PMC
|
15030555
|
PubMed citation
|
Europe PMC
|
15175101
|
PubMed citation
|
Europe PMC
|
15210365
|
PubMed citation
|
Europe PMC
|
15306697
|
PubMed citation
|
Europe PMC
|
15383526
|
PubMed citation
|
Europe PMC
|
15541012
|
PubMed citation
|
Europe PMC
|
15613074
|
PubMed citation
|
Europe PMC
|
15626898
|
PubMed citation
|
Europe PMC
|
15657176
|
PubMed citation
|
Europe PMC
|
1566062
|
PubMed citation
|
Europe PMC
|
15711594
|
PubMed citation
|
Europe PMC
|
15811524
|
PubMed citation
|
Europe PMC
|
15962181
|
PubMed citation
|
Europe PMC
|
16372476
|
PubMed citation
|
Europe PMC
|
16404634
|
PubMed citation
|
Europe PMC
|
16724420
|
PubMed citation
|
Europe PMC
|
16801218
|
PubMed citation
|
Europe PMC
|
16898534
|
PubMed citation
|
Europe PMC
|
17032751
|
PubMed citation
|
Europe PMC
|
17083576
|
PubMed citation
|
Europe PMC
|
17117422
|
PubMed citation
|
Europe PMC
|
17192032
|
PubMed citation
|
Europe PMC
|
17220244
|
PubMed citation
|
Europe PMC
|
17229932
|
PubMed citation
|
Europe PMC
|
17265451
|
PubMed citation
|
Europe PMC
|
17446460
|
PubMed citation
|
Europe PMC
|
17603747
|
PubMed citation
|
Europe PMC
|
18076075
|
PubMed citation
|
Europe PMC
|
18171316
|
PubMed citation
|
Europe PMC
|
18191430
|
PubMed citation
|
Europe PMC
|
18217899
|
PubMed citation
|
Europe PMC
|
18259730
|
PubMed citation
|
Europe PMC
|
18299432
|
PubMed citation
|
Europe PMC
|
18359899
|
PubMed citation
|
Europe PMC
|
18583716
|
PubMed citation
|
Europe PMC
|
18597363
|
PubMed citation
|
Europe PMC
|
18790203
|
PubMed citation
|
Europe PMC
|
18818682
|
PubMed citation
|
Europe PMC
|
18931077
|
PubMed citation
|
Europe PMC
|
18975184
|
PubMed citation
|
Europe PMC
|
19282398
|
PubMed citation
|
Europe PMC
|
19589783
|
PubMed citation
|
Europe PMC
|
21752960
|
PubMed citation
|
Europe PMC
|
23620378
|
PubMed citation
|
Europe PMC
|
24134630
|
PubMed citation
|
Europe PMC
|
31144214
|
PubMed citation
|
Europe PMC
|
34561200
|
PubMed citation
|
Europe PMC
|
34561814
|
PubMed citation
|
Europe PMC
|
|